STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PKH_141980Dihydrolipoamide succinyltransferase, putative. (415 aa)    
Predicted Functional Partners:
PKH_051030
2-oxoglutarate dehydrogenase e1 component,mitochondrial, putative.
 0.999
PKH_144930
Dihydrolipoyl dehydrogenase.
 
 0.996
PKH_051660
Dihydrolipoyl dehydrogenase, apicoplast, putative; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
 
 0.994
PKH_131870
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.990
PKH_090570
Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 0.978
PKH_102840
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial, putative.
 
 0.959
PKH_126000
Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 
 0.955
PKH_141180
2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
  
 0.950
PKH_060480
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.
  
0.916
PKH_125540
Acetyl-CoA acetyltransferase, putative; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.868
Your Current Organism:
Plasmodium knowlesi
NCBI taxonomy Id: 5851
Other names: P. knowlesi strain H, Plasmodium knowlesi (STRAIN H), Plasmodium knowlesi H, Plasmodium knowlesi Malayan H, Plasmodium knowlesi strain H
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.