STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
AEN95141.1COG4905 Predicted membrane protein. (387 aa)    
Predicted Functional Partners:
AEN96355.1
Putative R-2-hydroxyglutaryl-CoA dehydratase subunit/R-2-hydroxyglutaryl-CoA dehydratase activase; COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain).
 
     0.694
AEN95142.1
Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain.
       0.647
AEN96089.1
Hypothetical protein; COG1418 Predicted HD superfamily hydrolase.
     0.628
panC
Pantoate/beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
       0.548
panD
Aspartate alpha-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
       0.548
AEN97341.1
CoA-substrate-specific enzyme activase; COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain).
 
     0.489
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
       0.486
AEN95143.1
COG1838 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain.
       0.481
Your Current Organism:
Roseburia hominis
NCBI taxonomy Id: 585394
Other names: R. hominis A2-183, Roseburia hominis A2-183, Roseburia hominis str. A2-183, Roseburia hominis strain A2-183, butyrate-producing bacterium A2-183
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