Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEN95267.1Pseudaminic acid biosynthesis protein PseA; COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control. (389 aa)    
Predicted Functional Partners:
AEN95266.1
UDP-4-dehydro-6-deoxy-2-acetamido-D-glucose 4-reductase; COG1086 Predicted nucleoside-diphosphate sugar epimerases.
 
   
 0.905
hisH
Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.839
AEN95269.1
Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
   0.829
AEN95284.1
COG2089 Sialic acid synthase.
 
 
   0.745
AEN95276.1
COG1083 CMP-N-acetylneuraminic acid synthetase.
 
   
 0.679
AEN95282.1
Hypothetical protein; COG0456 Acetyltransferases.
 
    0.634
AEN95285.1
COG3980 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase.
 
     0.610
AEN95270.1
Multimeric flavodoxin domain-containing protein; COG0438 Glycosyltransferase.
  
    0.573
AEN95265.1
Hypothetical protein.
       0.526
pth
aminoacyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.
  
  
 0.508
Your Current Organism:
Roseburia hominis
NCBI taxonomy Id: 585394
Other names: R. hominis A2-183, Roseburia hominis A2-183, Roseburia hominis str. A2-183, Roseburia hominis strain A2-183, butyrate-producing bacterium A2-183
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