Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEN95392.1Two-component system, PleD related family, response regulator; COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain. (563 aa)    
Predicted Functional Partners:
AEN95559.1
Signaling protein; COG2199 FOG: GGDEF domain.
 
 
 0.925
AEN95379.1
PAS/PAC sensor hybrid histidine kinase; COG0784 FOG: CheY-like receiver.
 
  
 0.914
AEN96391.1
Diguanylate cyclase/phosphodiesterase; COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain.
 
 
0.900
AEN95395.1
GGDEF domain-containing protein; COG2199 FOG: GGDEF domain.
 
 
 0.840
AEN96314.1
COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain.
  
  
 0.836
AEN96184.1
GGDEF domain-containing protein; COG2199 FOG: GGDEF domain.
 
    0.815
AEN96871.1
Sensory transduction system regulatory protein; COG2199 FOG: GGDEF domain.
 
    0.807
AEN95157.1
Signaling protein; COG2199 FOG: GGDEF domain.
 
    0.804
AEN97720.1
Two-component system PleD-like family response regulator; COG2199 FOG: GGDEF domain.
  
    0.802
AEN96422.1
PAS/PAC sensor(s)-containing diguanylate cyclase/phosphodiesterase; COG2199 FOG: GGDEF domain.
  
    0.801
Your Current Organism:
Roseburia hominis
NCBI taxonomy Id: 585394
Other names: R. hominis A2-183, Roseburia hominis A2-183, Roseburia hominis str. A2-183, Roseburia hominis strain A2-183, butyrate-producing bacterium A2-183
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