Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
AEN95651.1Proposed homoserine kinase; COG3635 Predicted phosphoglycerate mutase, AP superfamily. (399 aa)    
Predicted Functional Partners:
pgk
COG0126 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.
    
 0.915
gpmI
Phosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
    
 0.909
eno-2
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
    
 0.907
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
    
 0.907
AEN96367.1
Hypothetical protein; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
    
 0.905
AEN97247.1
Hypothetical protein; COG1929 Glycerate kinase; Belongs to the glycerate kinase type-1 family.
     
  0.900
pgi
COG0166 Glucose-6-phosphate isomerase; Belongs to the GPI family.
   
 
 0.823
tal
Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily.
     
 0.805
AEN96327.1
Transketolase domain protein; COG3959 Transketolase, N-terminal subunit.
     
 0.803
AEN97970.1
Transketolase domain protein; COG3959 Transketolase, N-terminal subunit.
     
 0.803
Your Current Organism:
Roseburia hominis
NCBI taxonomy Id: 585394
Other names: R. hominis A2-183, Roseburia hominis A2-183, Roseburia hominis str. A2-183, Roseburia hominis strain A2-183, butyrate-producing bacterium A2-183
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