Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEN95708.1Nucleic acid methylase; COG0116 Predicted N6-adenine-specific DNA methylase. (390 aa)    
Predicted Functional Partners:
AEN95709.1
Cell surface protein; COG4870 Cysteine protease.
       0.817
AEN95713.1
Phosphodiesterase, MJ0936 family protein; COG0622 Predicted phosphoesterase.
     
 0.795
AEN95712.1
Ribonuclease Ph; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
       0.792
AEN95711.1
COG0860 N-acetylmuramoyl-L-alanine amidase.
       0.781
AEN95710.1
N-acetylmuramoyl-L-alanine amidase.
       0.737
AEN97064.1
Ribosomal biogenesis GTPase; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
 
  
 0.712
AEN96550.1
Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
   
    0.661
AEN95707.1
Rhodanese domain protein; COG0607 Rhodanese-related sulfurtransferase.
  
    0.623
pnp
Polynucleotide phosphorylase/polyadenylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.
   
    0.603
AEN96387.1
Exodeoxyribonuclease; COG0708 Exonuclease III.
  
    0.480
Your Current Organism:
Roseburia hominis
NCBI taxonomy Id: 585394
Other names: R. hominis A2-183, Roseburia hominis A2-183, Roseburia hominis str. A2-183, Roseburia hominis strain A2-183, butyrate-producing bacterium A2-183
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