Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEN95848.1GTP pyrophosphokinase; COG2357 Uncharacterized protein conserved in bacteria. (227 aa)    
Predicted Functional Partners:
AEN97980.1
RelA/SpoT domain-containing protein; COG2357 Uncharacterized protein conserved in bacteria.
  
  
 
0.913
AEN95201.1
COG2357 Uncharacterized protein conserved in bacteria.
  
  
 
0.912
AEN97439.1
(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
    
 0.910
AEN95750.1
Adenylate cyclase; COG2954 Uncharacterized protein conserved in bacteria.
     
  0.900
AEN96093.1
COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase.
     
  0.900
AEN96740.1
COG0248 Exopolyphosphatase.
     
  0.900
ribBA
GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
     
  0.800
AEN95849.1
Signaling protein; COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.
       0.781
AEN95850.1
ABC transporter-like protein; COG0488 ATPase components of ABC transporters with duplicated ATPase domains.
    
  0.759
mnmE
tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
   
    0.632
Your Current Organism:
Roseburia hominis
NCBI taxonomy Id: 585394
Other names: R. hominis A2-183, Roseburia hominis A2-183, Roseburia hominis str. A2-183, Roseburia hominis strain A2-183, butyrate-producing bacterium A2-183
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