Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEN95871.1Stage V sporulation protein AE; COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components. (118 aa)    
Predicted Functional Partners:
AEN95870.1
Stage V sporulation protein AD; COG0183 Acetyl-CoA acetyltransferase.
 
  
 0.980
AEN95857.1
Stage V sporulation AC, SpoVAC.
 
  
 0.914
AEN95800.1
COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor); Belongs to the anti-sigma-factor antagonist family.
 
     0.829
spoIIAB
Putative anti-sigma regulatory factor, serine/threonine protein kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
 
     0.828
AEN96872.1
Stage IV sporulation protein B; COG0750 Predicted membrane-associated Zn-dependent proteases 1.
  
   
 0.802
AEN96929.1
Stage III sporulation protein AD.
  
   
 0.792
gpr
Germination protease; Initiates the rapid degradation of small, acid-soluble proteins during spore germination; Belongs to the peptidase A25 family.
  
  
 0.786
AEN96932.1
Stage III sporulation protein AA; COG3854 Uncharacterized protein conserved in bacteria.
  
   
 0.785
AEN96446.1
Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
  
   
 0.784
AEN96496.1
Sporulation sigma factor SigK; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
     0.782
Your Current Organism:
Roseburia hominis
NCBI taxonomy Id: 585394
Other names: R. hominis A2-183, Roseburia hominis A2-183, Roseburia hominis str. A2-183, Roseburia hominis strain A2-183, butyrate-producing bacterium A2-183
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