node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AEN96021.1 | hslO | RHOM_04495 | RHOM_04485 | COG1453 Predicted oxidoreductases of the aldo/keto reductase family. | Chaperonin, 33 kDa; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. | 0.773 |
AEN96021.1 | nadE | RHOM_04495 | RHOM_04490 | COG1453 Predicted oxidoreductases of the aldo/keto reductase family. | NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.784 |
AEN96742.1 | birA | RHOM_08145 | RHOM_15695 | Prephenate dehydratase; COG1605 Chorismate mutase. | Putative transcriptional repressor of the biotin operon birA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.530 |
AEN96742.1 | guaA | RHOM_08145 | RHOM_13030 | Prephenate dehydratase; COG1605 Chorismate mutase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.703 |
AEN96742.1 | nadE | RHOM_08145 | RHOM_04490 | Prephenate dehydratase; COG1605 Chorismate mutase. | NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.767 |
AEN97314.1 | AEN97480.1 | RHOM_11025 | RHOM_11860 | Hypothetical protein; COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding. | Hypothetical protein; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | 0.921 |
AEN97314.1 | cobB | RHOM_11025 | RHOM_16655 | Hypothetical protein; COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding. | NAD-dependent deacetylase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | 0.918 |
AEN97314.1 | nadD | RHOM_11025 | RHOM_07560 | Hypothetical protein; COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.906 |
AEN97314.1 | nadE | RHOM_11025 | RHOM_04490 | Hypothetical protein; COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding. | NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.915 |
AEN97314.1 | nadK | RHOM_11025 | RHOM_08820 | Hypothetical protein; COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding. | ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.902 |
AEN97480.1 | AEN97314.1 | RHOM_11860 | RHOM_11025 | Hypothetical protein; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | Hypothetical protein; COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding. | 0.921 |
AEN97480.1 | birA | RHOM_11860 | RHOM_15695 | Hypothetical protein; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | Putative transcriptional repressor of the biotin operon birA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.500 |
AEN97480.1 | cobB | RHOM_11860 | RHOM_16655 | Hypothetical protein; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | NAD-dependent deacetylase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | 0.422 |
AEN97480.1 | guaA | RHOM_11860 | RHOM_13030 | Hypothetical protein; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.466 |
AEN97480.1 | nadD | RHOM_11860 | RHOM_07560 | Hypothetical protein; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.951 |
AEN97480.1 | nadE | RHOM_11860 | RHOM_04490 | Hypothetical protein; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.780 |
birA | AEN96742.1 | RHOM_15695 | RHOM_08145 | Putative transcriptional repressor of the biotin operon birA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Prephenate dehydratase; COG1605 Chorismate mutase. | 0.530 |
birA | AEN97480.1 | RHOM_15695 | RHOM_11860 | Putative transcriptional repressor of the biotin operon birA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Hypothetical protein; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | 0.500 |
birA | guaA | RHOM_15695 | RHOM_13030 | Putative transcriptional repressor of the biotin operon birA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.676 |
birA | nadD | RHOM_15695 | RHOM_07560 | Putative transcriptional repressor of the biotin operon birA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.528 |