Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEN96025.1PP-loop domain protein; COG1606 ATP-utilizing enzymes of the PP-loop superfamily. (271 aa)    
Predicted Functional Partners:
AEN96399.1
1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase; COG1691 NCAIR mutase (PurE)-related proteins.
 
  
 0.973
larC
Hypothetical protein; Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes. Belongs to the LarC family.
  
 0.943
AEN96024.1
COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters.
  
    0.721
nth
DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
 
    0.715
AEN96023.1
COG1122 ABC-type cobalt transport system, ATPase component.
       0.668
AEN98071.1
Hypothetical protein; COG0607 Rhodanese-related sulfurtransferase; Belongs to the TtcA family.
 
    0.601
AEN96021.1
COG1453 Predicted oxidoreductases of the aldo/keto reductase family.
 
    0.539
AEN96026.1
COG0765 ABC-type amino acid transport system, permease component.
  
    0.458
AEN96027.1
COG0765 ABC-type amino acid transport system, permease component.
  
    0.458
AEN96028.1
Fe(3+)-transporting ATPase; COG1126 ABC-type polar amino acid transport system, ATPase component.
       0.443
Your Current Organism:
Roseburia hominis
NCBI taxonomy Id: 585394
Other names: R. hominis A2-183, Roseburia hominis A2-183, Roseburia hominis str. A2-183, Roseburia hominis strain A2-183, butyrate-producing bacterium A2-183
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