STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEN96045.1Transcriptional regulator, BadM/Rrf2 family protein; COG1959 Predicted transcriptional regulator. (140 aa)    
Predicted Functional Partners:
AEN96043.1
COG0822 NifU homolog involved in Fe-S cluster formation.
 
  
 0.881
iscS
Cysteine desulfurase NifS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
  
  
 0.848
AEN96044.1
Hypothetical protein.
     
 0.778
AEN96046.1
Transcriptional regulator, BadM/Rrf2 family protein; COG1959 Predicted transcriptional regulator.
 
    
0.760
AEN96144.1
Cysteine desulfurase NifS; COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes.
  
  
 0.538
AEN96209.1
COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes.
  
  
 0.538
lepA
GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.
  
  
 0.440
AEN97148.1
Nitrogen fixation protein NifU-like protein; COG0822 NifU homolog involved in Fe-S cluster formation.
  
  
 0.432
AEN96825.1
Hypothetical protein; COG0822 NifU homolog involved in Fe-S cluster formation.
  
  
 0.416
Your Current Organism:
Roseburia hominis
NCBI taxonomy Id: 585394
Other names: R. hominis A2-183, Roseburia hominis A2-183, Roseburia hominis str. A2-183, Roseburia hominis strain A2-183, butyrate-producing bacterium A2-183
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.