Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEN96422.1PAS/PAC sensor(s)-containing diguanylate cyclase/phosphodiesterase; COG2199 FOG: GGDEF domain. (171 aa)    
Predicted Functional Partners:
AEN96391.1
Diguanylate cyclase/phosphodiesterase; COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain.
 
  
 0.883
AEN98437.1
COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain.
 
  
 0.858
AEN95849.1
Signaling protein; COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.
  
    0.807
AEN97310.1
EAL domain-containing protein; COG2200 FOG: EAL domain.
  
    0.807
AEN97992.1
Sensory transduction protein kinase; COG2200 FOG: EAL domain.
  
    0.807
AEN95792.1
Two-component system, PleD related family, response regulator; COG2199 FOG: GGDEF domain.
  
    0.806
AEN95392.1
Two-component system, PleD related family, response regulator; COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.
  
    0.801
AEN95395.1
GGDEF domain-containing protein; COG2199 FOG: GGDEF domain.
  
   0.779
AEN97886.1
Diguanylate cyclase; COG2199 FOG: GGDEF domain.
  
     0.774
AEN96299.1
Metal dependent phosphohydrolase; COG2206 HD-GYP domain.
  
   0.749
Your Current Organism:
Roseburia hominis
NCBI taxonomy Id: 585394
Other names: R. hominis A2-183, Roseburia hominis A2-183, Roseburia hominis str. A2-183, Roseburia hominis strain A2-183, butyrate-producing bacterium A2-183
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