Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEN97000.1Aminotransferase class I and II; COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities. (391 aa)    
Predicted Functional Partners:
AEN97331.1
COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases.
 
 
 0.931
AEN97353.1
COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain.
     
 0.919
AEN96937.1
COG2873 O-acetylhomoserine sulfhydrylase.
    
 0.912
AEN98075.1
COG0031 Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.
    
 0.910
luxS
S-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
     
 0.902
AEN97295.1
COG0436 Aspartate/tyrosine/aromatic aminotransferase.
     
0.902
AEN97075.1
COG1171 Threonine dehydratase.
    
  0.806
AEN96591.1
Aminoacyl-histidine dipeptidase; COG2195 Di- and tripeptidases.
    
  0.804
AEN95650.1
COG0460 Homoserine dehydrogenase.
    
  0.800
AEN95704.1
Phosphopantothenoylcysteine decarboxylase / phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.
    
  0.800
Your Current Organism:
Roseburia hominis
NCBI taxonomy Id: 585394
Other names: R. hominis A2-183, Roseburia hominis A2-183, Roseburia hominis str. A2-183, Roseburia hominis strain A2-183, butyrate-producing bacterium A2-183
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