Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (299 aa)    
Predicted Functional Partners:
thiE
Hypothetical protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
 0.999
AEN97791.1
COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase.
  
 0.995
AEN96897.1
NUDIX hydrolase; COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes.
     
  0.900
AEN98052.1
Hypothetical protein; COG0637 Predicted phosphatase/phosphohexomutase.
       0.808
AEN98050.1
Hypothetical protein; COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily.
       0.773
AEN98051.1
Ectoine/hydroxyectoine ABC transporter ATP-binding protein; COG1126 ABC-type polar amino acid transport system, ATPase component.
       0.773
thiC
Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.719
AEN97790.1
Putative hydroxymethylpyrimidine transporter CytX; COG1457 Purine-cytosine permease and related proteins.
 
    0.676
thiH
COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes.
  
  
 0.527
AEN97789.1
COG4732 Predicted membrane protein.
 
     0.509
Your Current Organism:
Roseburia hominis
NCBI taxonomy Id: 585394
Other names: R. hominis A2-183, Roseburia hominis A2-183, Roseburia hominis str. A2-183, Roseburia hominis strain A2-183, butyrate-producing bacterium A2-183
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