Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEN98073.1Quinolinate synthetase complex, subunit alpha; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (307 aa)    
Predicted Functional Partners:
AEN96577.1
Fumarate reductase/succinate dehydrogenase flavoprotein domain protein; COG0029 Aspartate oxidase.
 
 0.999
AEN96578.1
COG0157 Nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family.
 
 
 0.998
AEN97035.1
Aspartate dehydrogenase; COG1712 Predicted dinucleotide-utilizing enzyme.
    
 0.922
AEN97351.1
COG1045 Serine acetyltransferase.
  
    0.830
AEN98071.1
Hypothetical protein; COG0607 Rhodanese-related sulfurtransferase; Belongs to the TtcA family.
     
 0.706
valS
valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
      0.672
AEN98472.1
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
  
  
 0.653
nadE
NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
  
 0.629
birA
Putative transcriptional repressor of the biotin operon birA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
     
 0.617
AEN98072.1
UBA/THIF-type NAD/FAD binding protein; COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1.
       0.594
Your Current Organism:
Roseburia hominis
NCBI taxonomy Id: 585394
Other names: R. hominis A2-183, Roseburia hominis A2-183, Roseburia hominis str. A2-183, Roseburia hominis strain A2-183, butyrate-producing bacterium A2-183
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