Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEN98181.1DNA topoisomerase III; COG0550 Topoisomerase IA. (699 aa)    
Predicted Functional Partners:
AEN98182.1
Hypothetical protein.
 
   
 0.847
AEN98185.1
Hypothetical protein; COG3451 Type IV secretory pathway, VirB4 components.
 
  
 0.847
AEN98184.1
Peptidase, M23 family protein; COG0739 Membrane proteins related to metalloendopeptidases.
 
     0.810
AEN98186.1
Hypothetical protein; COG1174 ABC-type proline/glycine betaine transport systems, permease component.
 
    0.782
AEN98183.1
Hypothetical protein.
       0.779
AEN98180.1
Hypothetical protein; COG1396 Predicted transcriptional regulators.
       0.741
AEN98179.1
COG0827 Adenine-specific DNA methylase.
 
     0.733
AEN98187.1
Hypothetical protein.
 
     0.726
AEN96087.1
Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit.
  
   0.725
recA
Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.700
Your Current Organism:
Roseburia hominis
NCBI taxonomy Id: 585394
Other names: R. hominis A2-183, Roseburia hominis A2-183, Roseburia hominis str. A2-183, Roseburia hominis strain A2-183, butyrate-producing bacterium A2-183
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