Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AEN98346.1Radical SAM domain-containing protein; COG0535 Predicted Fe-S oxidoreductases. (397 aa)    
Predicted Functional Partners:
AEN98347.1
Radical SAM domain-containing protein; COG0641 Arylsulfatase regulator (Fe-S oxidoreductase).
 
   
 0.847
AEN98348.1
Lipid A export ATP-binding/permease MsbA; COG1132 ABC-type multidrug transport system, ATPase and permease components.
       0.773
AEN98345.1
Hypothetical protein.
       0.642
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
   
  
 0.574
AEN98343.1
Radical SAM domain-containing protein; COG0535 Predicted Fe-S oxidoreductases.
 
  
0.530
AEN96991.1
NADPH-dependent glutamate synthase GltA2; COG1145 Ferredoxin.
 
  
 0.519
AEN98349.1
Hypothetical protein; COG0577 ABC-type antimicrobial peptide transport system, permease component.
 
     0.494
AEN95877.1
Hypothetical protein; COG0546 Predicted phosphatases.
  
    0.490
AEN95971.1
Hypothetical protein; COG0546 Predicted phosphatases.
  
    0.490
AEN97044.1
Putative phosphatase, HAD family protein; COG0546 Predicted phosphatases.
  
    0.490
Your Current Organism:
Roseburia hominis
NCBI taxonomy Id: 585394
Other names: R. hominis A2-183, Roseburia hominis A2-183, Roseburia hominis str. A2-183, Roseburia hominis strain A2-183, butyrate-producing bacterium A2-183
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.