Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Experiments
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[Homology]
Score
AEN98416.1COG2003 DNA repair proteins. (179 aa)    
Predicted Functional Partners:
AEN96337.1
Maf-like protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
 
  
 0.834
AEN98415.1
Hypothetical protein; COG0358 DNA primase (bacterial type).
 
     0.805
AEN96652.1
Rod shape-determining protein MreC; Involved in formation and maintenance of cell shape.
  
  
 0.776
AEN96245.1
COG0658 Predicted membrane metal-binding protein.
 
  
 0.613
mutS
DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
 
   
 0.606
AEN98418.1
Hypothetical protein.
 
     0.584
AEN96498.1
COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake.
  
  
 0.581
AEN97593.1
COG1040 Predicted amidophosphoribosyltransferases.
 
    0.575
AEN96873.1
DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.
  
   
 0.541
mutL
DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
 
   
 0.506
Your Current Organism:
Roseburia hominis
NCBI taxonomy Id: 585394
Other names: R. hominis A2-183, Roseburia hominis A2-183, Roseburia hominis str. A2-183, Roseburia hominis strain A2-183, butyrate-producing bacterium A2-183
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