STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
EEJ52619.1Thiamine pyrophosphate enzyme, central domain protein; COG: COG0028; Belongs to the TPP enzyme family. (727 aa)    
Predicted Functional Partners:
nifJ
Pyruvate synthase; COG: COG0674.
  
 
 0.954
ilvN
Acetolactate synthase, small subunit; COG: COG0440.
 
 0.953
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.952
EEJ52618.1
NAD dependent epimerase/dehydratase family protein.
 
 
   0.880
ilvH2
Acetolactate synthase-like protein; COG: COG0440.
  
 0.879
ilvD
Dihydroxy-acid dehydratase; COG: COG0129; Belongs to the IlvD/Edd family.
 
 
 0.865
pyk
Pyruvate kinase; COG: COG0469; Belongs to the pyruvate kinase family.
  
 0.854
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 0.839
ilvA
Threonine ammonia-lyase; COG: COG1171.
  
 0.762
ldh
L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.
  
 0.747
Your Current Organism:
Oribacterium sinus
NCBI taxonomy Id: 585501
Other names: O. sinus F0268, Oribacterium sinus F0268, Oribacterium sinus str. F0268, Oribacterium sinus strain F0268
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