node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EEJ52422.1 | EEJ52423.1 | HMPREF6123_0294 | HMPREF6123_0295 | Hypothetical protein. | Tat pathway signal sequence domain protein. | 0.569 |
EEJ52422.1 | folA | HMPREF6123_0294 | HMPREF6123_0296 | Hypothetical protein. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.541 |
EEJ52423.1 | EEJ52422.1 | HMPREF6123_0295 | HMPREF6123_0294 | Tat pathway signal sequence domain protein. | Hypothetical protein. | 0.569 |
EEJ52423.1 | folA | HMPREF6123_0295 | HMPREF6123_0296 | Tat pathway signal sequence domain protein. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.736 |
fhs | fmt | HMPREF6123_0452 | HMPREF6123_0457 | Formate--tetrahydrofolate ligase; COG: COG2759; Belongs to the formate--tetrahydrofolate ligase family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.975 |
fhs | folA | HMPREF6123_0452 | HMPREF6123_0296 | Formate--tetrahydrofolate ligase; COG: COG2759; Belongs to the formate--tetrahydrofolate ligase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.902 |
fhs | folC | HMPREF6123_0452 | HMPREF6123_0777 | Formate--tetrahydrofolate ligase; COG: COG2759; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional protein FolC; COG: COG0285; Belongs to the folylpolyglutamate synthase family. | 0.662 |
fhs | gcvT | HMPREF6123_0452 | HMPREF6123_1177 | Formate--tetrahydrofolate ligase; COG: COG2759; Belongs to the formate--tetrahydrofolate ligase family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.935 |
fhs | glyA | HMPREF6123_0452 | HMPREF6123_1078 | Formate--tetrahydrofolate ligase; COG: COG2759; Belongs to the formate--tetrahydrofolate ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.978 |
fmt | fhs | HMPREF6123_0457 | HMPREF6123_0452 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Formate--tetrahydrofolate ligase; COG: COG2759; Belongs to the formate--tetrahydrofolate ligase family. | 0.975 |
fmt | folA | HMPREF6123_0457 | HMPREF6123_0296 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.901 |
fmt | gcvT | HMPREF6123_0457 | HMPREF6123_1177 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.912 |
fmt | glyA | HMPREF6123_0457 | HMPREF6123_1078 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.936 |
folA | EEJ52422.1 | HMPREF6123_0296 | HMPREF6123_0294 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Hypothetical protein. | 0.541 |
folA | EEJ52423.1 | HMPREF6123_0296 | HMPREF6123_0295 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Tat pathway signal sequence domain protein. | 0.736 |
folA | fhs | HMPREF6123_0296 | HMPREF6123_0452 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Formate--tetrahydrofolate ligase; COG: COG2759; Belongs to the formate--tetrahydrofolate ligase family. | 0.902 |
folA | fmt | HMPREF6123_0296 | HMPREF6123_0457 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.901 |
folA | folC | HMPREF6123_0296 | HMPREF6123_0777 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Bifunctional protein FolC; COG: COG0285; Belongs to the folylpolyglutamate synthase family. | 0.952 |
folA | gcvT | HMPREF6123_0296 | HMPREF6123_1177 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.896 |
folA | glyA | HMPREF6123_0296 | HMPREF6123_1078 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.910 |