STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvNAcetolactate synthase, small subunit; COG: COG0440. (162 aa)    
Predicted Functional Partners:
ilvB
Acetolactate synthase, large subunit, biosynthetic type; COG: COG0028.
 0.999
ilvB-2
Acetolactate synthase, large subunit, biosynthetic type; COG: COG0028.
 0.999
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.998
ilvA
Threonine ammonia-lyase; COG: COG1171.
  
 
 0.990
EEJ52619.1
Thiamine pyrophosphate enzyme, central domain protein; COG: COG0028; Belongs to the TPP enzyme family.
 0.980
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 0.975
ilvH2
Acetolactate synthase-like protein; COG: COG0440.
 
  
 
0.961
nifJ
Pyruvate synthase; COG: COG0674.
  
 
 0.939
leuA
Putative 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate).
  
 
 0.924
EEJ52363.1
Hypothetical protein.
  
 
 0.924
Your Current Organism:
Oribacterium sinus
NCBI taxonomy Id: 585501
Other names: O. sinus F0268, Oribacterium sinus F0268, Oribacterium sinus str. F0268, Oribacterium sinus strain F0268
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