node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EFK55331.1 | EFK55409.1 | HMPREF0291_10589 | HMPREF0291_10667 | Membrane protein insertase, YidC/Oxa1 family; COG: COG0706; Pfam: PF02096; InterPro: IPR001708. | Putative inner membrane protein translocase component YidC; COG: COG0706; Pfam: PF02096; InterPro: IPR001708. | 0.915 |
EFK55331.1 | ffh | HMPREF0291_10589 | HMPREF0291_11341 | Membrane protein insertase, YidC/Oxa1 family; COG: COG0706; Pfam: PF02096; InterPro: IPR001708. | Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 0.935 |
EFK55331.1 | ftsY | HMPREF0291_10589 | HMPREF0291_11340 | Membrane protein insertase, YidC/Oxa1 family; COG: COG0706; Pfam: PF02096; InterPro: IPR001708. | Signal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | 0.921 |
EFK55331.1 | secA | HMPREF0291_10589 | HMPREF0291_10035 | Membrane protein insertase, YidC/Oxa1 family; COG: COG0706; Pfam: PF02096; InterPro: IPR001708. | Preprotein translocase, SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.935 |
EFK55331.1 | secA-2 | HMPREF0291_10589 | HMPREF0291_11653 | Membrane protein insertase, YidC/Oxa1 family; COG: COG0706; Pfam: PF02096; InterPro: IPR001708. | SecA cross-linking domain protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.938 |
EFK55331.1 | secD | HMPREF0291_10589 | HMPREF0291_11487 | Membrane protein insertase, YidC/Oxa1 family; COG: COG0706; Pfam: PF02096; InterPro: IPR001708. | Export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.948 |
EFK55331.1 | secE | HMPREF0291_10589 | HMPREF0291_10296 | Membrane protein insertase, YidC/Oxa1 family; COG: COG0706; Pfam: PF02096; InterPro: IPR001708. | Preprotein translocase, SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. | 0.972 |
EFK55331.1 | secG | HMPREF0291_10589 | HMPREF0291_11561 | Membrane protein insertase, YidC/Oxa1 family; COG: COG0706; Pfam: PF02096; InterPro: IPR001708. | Preprotein translocase, SecG subunit; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | 0.983 |
EFK55331.1 | secY | HMPREF0291_10589 | HMPREF0291_10232 | Membrane protein insertase, YidC/Oxa1 family; COG: COG0706; Pfam: PF02096; InterPro: IPR001708. | Preprotein translocase, SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.990 |
EFK55331.1 | yajC | HMPREF0291_10589 | HMPREF0291_11486 | Membrane protein insertase, YidC/Oxa1 family; COG: COG0706; Pfam: PF02096; InterPro: IPR001708. | Preprotein translocase, YajC subunit; Pfam: PF02699. | 0.933 |
EFK55409.1 | EFK55331.1 | HMPREF0291_10667 | HMPREF0291_10589 | Putative inner membrane protein translocase component YidC; COG: COG0706; Pfam: PF02096; InterPro: IPR001708. | Membrane protein insertase, YidC/Oxa1 family; COG: COG0706; Pfam: PF02096; InterPro: IPR001708. | 0.915 |
EFK55409.1 | ffh | HMPREF0291_10667 | HMPREF0291_11341 | Putative inner membrane protein translocase component YidC; COG: COG0706; Pfam: PF02096; InterPro: IPR001708. | Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 0.935 |
EFK55409.1 | ftsY | HMPREF0291_10667 | HMPREF0291_11340 | Putative inner membrane protein translocase component YidC; COG: COG0706; Pfam: PF02096; InterPro: IPR001708. | Signal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | 0.921 |
EFK55409.1 | secA | HMPREF0291_10667 | HMPREF0291_10035 | Putative inner membrane protein translocase component YidC; COG: COG0706; Pfam: PF02096; InterPro: IPR001708. | Preprotein translocase, SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.924 |
EFK55409.1 | secA-2 | HMPREF0291_10667 | HMPREF0291_11653 | Putative inner membrane protein translocase component YidC; COG: COG0706; Pfam: PF02096; InterPro: IPR001708. | SecA cross-linking domain protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.916 |
EFK55409.1 | secD | HMPREF0291_10667 | HMPREF0291_11487 | Putative inner membrane protein translocase component YidC; COG: COG0706; Pfam: PF02096; InterPro: IPR001708. | Export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.936 |
EFK55409.1 | secE | HMPREF0291_10667 | HMPREF0291_10296 | Putative inner membrane protein translocase component YidC; COG: COG0706; Pfam: PF02096; InterPro: IPR001708. | Preprotein translocase, SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. | 0.968 |
EFK55409.1 | secG | HMPREF0291_10667 | HMPREF0291_11561 | Putative inner membrane protein translocase component YidC; COG: COG0706; Pfam: PF02096; InterPro: IPR001708. | Preprotein translocase, SecG subunit; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | 0.983 |
EFK55409.1 | secY | HMPREF0291_10667 | HMPREF0291_10232 | Putative inner membrane protein translocase component YidC; COG: COG0706; Pfam: PF02096; InterPro: IPR001708. | Preprotein translocase, SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.989 |
EFK55409.1 | yajC | HMPREF0291_10667 | HMPREF0291_11486 | Putative inner membrane protein translocase component YidC; COG: COG0706; Pfam: PF02096; InterPro: IPR001708. | Preprotein translocase, YajC subunit; Pfam: PF02699. | 0.903 |