node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EFK53951.1 | EFK53952.1 | HMPREF0291_11608 | HMPREF0291_11609 | Hypothetical protein. | HAD hydrolase, family IA, variant 3; COG: COG0637; Pfam: PF00702; InterPro: IPR005834. | 0.781 |
EFK53951.1 | hisE | HMPREF0291_11608 | HMPREF0291_11610 | Hypothetical protein. | phosphoribosyl-ATP diphosphatase; COG: COG0140; Pfam: PF01503; InterPro: IPR008179. | 0.781 |
EFK53951.1 | hisG | HMPREF0291_11608 | HMPREF0291_11611 | Hypothetical protein. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.746 |
EFK53952.1 | EFK53951.1 | HMPREF0291_11609 | HMPREF0291_11608 | HAD hydrolase, family IA, variant 3; COG: COG0637; Pfam: PF00702; InterPro: IPR005834. | Hypothetical protein. | 0.781 |
EFK53952.1 | hisE | HMPREF0291_11609 | HMPREF0291_11610 | HAD hydrolase, family IA, variant 3; COG: COG0637; Pfam: PF00702; InterPro: IPR005834. | phosphoribosyl-ATP diphosphatase; COG: COG0140; Pfam: PF01503; InterPro: IPR008179. | 0.843 |
EFK53952.1 | hisG | HMPREF0291_11609 | HMPREF0291_11611 | HAD hydrolase, family IA, variant 3; COG: COG0637; Pfam: PF00702; InterPro: IPR005834. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.802 |
hisA | hisB | HMPREF0291_11311 | HMPREF0291_11305 | Bifunctional HisA/TrpF protein; COG: COG0106; Pfam: PF00977; InterPro: IPR010188. | Imidazoleglycerol-phosphate dehydratase; COG: COG0131; Pfam: PF00475; InterPro: IPR000807. | 0.999 |
hisA | hisC | HMPREF0291_11311 | HMPREF0291_11304 | Bifunctional HisA/TrpF protein; COG: COG0106; Pfam: PF00977; InterPro: IPR010188. | Histidinol-phosphate transaminase; COG: COG0079; Pfam: PF00155; InterPro: IPR005861; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.978 |
hisA | hisD | HMPREF0291_11311 | HMPREF0291_11303 | Bifunctional HisA/TrpF protein; COG: COG0106; Pfam: PF00977; InterPro: IPR010188. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisA | hisE | HMPREF0291_11311 | HMPREF0291_11610 | Bifunctional HisA/TrpF protein; COG: COG0106; Pfam: PF00977; InterPro: IPR010188. | phosphoribosyl-ATP diphosphatase; COG: COG0140; Pfam: PF01503; InterPro: IPR008179. | 0.991 |
hisA | hisF | HMPREF0291_11311 | HMPREF0291_11313 | Bifunctional HisA/TrpF protein; COG: COG0106; Pfam: PF00977; InterPro: IPR010188. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | HMPREF0291_11311 | HMPREF0291_11611 | Bifunctional HisA/TrpF protein; COG: COG0106; Pfam: PF00977; InterPro: IPR010188. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.996 |
hisA | hisH | HMPREF0291_11311 | HMPREF0291_11310 | Bifunctional HisA/TrpF protein; COG: COG0106; Pfam: PF00977; InterPro: IPR010188. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | HMPREF0291_11311 | HMPREF0291_11314 | Bifunctional HisA/TrpF protein; COG: COG0106; Pfam: PF00977; InterPro: IPR010188. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisB | hisA | HMPREF0291_11305 | HMPREF0291_11311 | Imidazoleglycerol-phosphate dehydratase; COG: COG0131; Pfam: PF00475; InterPro: IPR000807. | Bifunctional HisA/TrpF protein; COG: COG0106; Pfam: PF00977; InterPro: IPR010188. | 0.999 |
hisB | hisC | HMPREF0291_11305 | HMPREF0291_11304 | Imidazoleglycerol-phosphate dehydratase; COG: COG0131; Pfam: PF00475; InterPro: IPR000807. | Histidinol-phosphate transaminase; COG: COG0079; Pfam: PF00155; InterPro: IPR005861; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | HMPREF0291_11305 | HMPREF0291_11303 | Imidazoleglycerol-phosphate dehydratase; COG: COG0131; Pfam: PF00475; InterPro: IPR000807. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisE | HMPREF0291_11305 | HMPREF0291_11610 | Imidazoleglycerol-phosphate dehydratase; COG: COG0131; Pfam: PF00475; InterPro: IPR000807. | phosphoribosyl-ATP diphosphatase; COG: COG0140; Pfam: PF01503; InterPro: IPR008179. | 0.996 |
hisB | hisF | HMPREF0291_11305 | HMPREF0291_11313 | Imidazoleglycerol-phosphate dehydratase; COG: COG0131; Pfam: PF00475; InterPro: IPR000807. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | HMPREF0291_11305 | HMPREF0291_11611 | Imidazoleglycerol-phosphate dehydratase; COG: COG0131; Pfam: PF00475; InterPro: IPR000807. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.995 |