| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFG47954.1 | mraW | HMPREF0183_0730 | HMPREF0183_0444 | Metallo-beta-lactamase domain protein; COG: COG0491; Pfam: PF00753,PF00581; InterPro: IPR001279. | S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. | 0.968 |
| EFG48189.1 | mraW | HMPREF0183_0446 | HMPREF0183_0444 | Penicillin-binding protein, transpeptidase domain protein; COG: COG0768; Pfam: PF03717,PF00905; InterPro: IPR001460. | S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. | 0.856 |
| EFG48189.1 | mraZ | HMPREF0183_0446 | HMPREF0183_0443 | Penicillin-binding protein, transpeptidase domain protein; COG: COG0768; Pfam: PF03717,PF00905; InterPro: IPR001460. | Protein MraZ; COG: COG2001; Pfam: PF02381; InterPro: IPR003444; Belongs to the MraZ family. | 0.676 |
| EFG48189.1 | murE | HMPREF0183_0446 | HMPREF0183_0447 | Penicillin-binding protein, transpeptidase domain protein; COG: COG0768; Pfam: PF03717,PF00905; InterPro: IPR001460. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.976 |
| EFG48189.1 | murG | HMPREF0183_0446 | HMPREF0183_0452 | Penicillin-binding protein, transpeptidase domain protein; COG: COG0768; Pfam: PF03717,PF00905; InterPro: IPR001460. | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.966 |
| mraW | EFG47954.1 | HMPREF0183_0444 | HMPREF0183_0730 | S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. | Metallo-beta-lactamase domain protein; COG: COG0491; Pfam: PF00753,PF00581; InterPro: IPR001279. | 0.968 |
| mraW | EFG48189.1 | HMPREF0183_0444 | HMPREF0183_0446 | S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. | Penicillin-binding protein, transpeptidase domain protein; COG: COG0768; Pfam: PF03717,PF00905; InterPro: IPR001460. | 0.856 |
| mraW | mraZ | HMPREF0183_0444 | HMPREF0183_0443 | S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. | Protein MraZ; COG: COG2001; Pfam: PF02381; InterPro: IPR003444; Belongs to the MraZ family. | 0.996 |
| mraW | murE | HMPREF0183_0444 | HMPREF0183_0447 | S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.776 |
| mraW | murG | HMPREF0183_0444 | HMPREF0183_0452 | S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.792 |
| mraW | rpsF | HMPREF0183_0444 | HMPREF0183_0577 | S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. | Ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. | 0.780 |
| mraW | rpsI | HMPREF0183_0444 | HMPREF0183_0860 | S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. | Ribosomal protein S9; COG: COG0103; Pfam: PF00380; InterPro: IPR000754; Belongs to the universal ribosomal protein uS9 family. | 0.808 |
| mraW | rpsO | HMPREF0183_0444 | HMPREF0183_1076 | S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. | Ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. | 0.752 |
| mraW | rpsP | HMPREF0183_0444 | HMPREF0183_1727 | S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. | Ribosomal protein S16; COG: COG0228; Pfam: PF00886; InterPro: IPR000307; Belongs to the bacterial ribosomal protein bS16 family. | 0.776 |
| mraW | rsmI | HMPREF0183_0444 | HMPREF0183_1852 | S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. | S-adenosylmethionine-dependent methyltransferase, YraL family; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. | 0.825 |
| mraZ | EFG48189.1 | HMPREF0183_0443 | HMPREF0183_0446 | Protein MraZ; COG: COG2001; Pfam: PF02381; InterPro: IPR003444; Belongs to the MraZ family. | Penicillin-binding protein, transpeptidase domain protein; COG: COG0768; Pfam: PF03717,PF00905; InterPro: IPR001460. | 0.676 |
| mraZ | mraW | HMPREF0183_0443 | HMPREF0183_0444 | Protein MraZ; COG: COG2001; Pfam: PF02381; InterPro: IPR003444; Belongs to the MraZ family. | S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. | 0.996 |
| mraZ | murE | HMPREF0183_0443 | HMPREF0183_0447 | Protein MraZ; COG: COG2001; Pfam: PF02381; InterPro: IPR003444; Belongs to the MraZ family. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.635 |
| mraZ | murG | HMPREF0183_0443 | HMPREF0183_0452 | Protein MraZ; COG: COG2001; Pfam: PF02381; InterPro: IPR003444; Belongs to the MraZ family. | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.620 |
| murE | EFG48189.1 | HMPREF0183_0447 | HMPREF0183_0446 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | Penicillin-binding protein, transpeptidase domain protein; COG: COG0768; Pfam: PF03717,PF00905; InterPro: IPR001460. | 0.976 |