Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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gcvPGlycine dehydrogenase; COG: COG1003; Pfam: PF02347,PF01212; InterPro: IPR003437; Belongs to the GcvP family. (990 aa)    
Predicted Functional Partners:
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 0.999
gcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.
 0.999
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.996
sucA
Oxoglutarate dehydrogenase (succinyl-transferring), E1 component; COG: COG0567; Pfam: PF00198,PF00676,PF02779; InterPro: IPR011603.
  
 
 0.992
folD
Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
 
 0.977
fhs
Formate--tetrahydrofolate ligase; COG: COG2759; Pfam: PF01268; InterPro: IPR000559; Belongs to the formate--tetrahydrofolate ligase family.
  
 
 0.973
EFG47935.1
Methylenetetrahydrofolate reductase (NAD(P)H); COG: COG0685; Pfam: PF02219; InterPro: IPR003171; Belongs to the methylenetetrahydrofolate reductase family.
    
 0.958
purC
Phosphoribosylaminoimidazolesuccinocarboxamide synthase; COG: COG0151; Pfam: PF02844,PF01071,PF02843,PF01259; InterPro: IPR000115; Belongs to the GARS family.
  
  
 0.957
EFG46757.1
Hypothetical protein; COG: COG1951; Pfam: PF05681; InterPro: IPR004646; 4.2.1.2.
   
  
 0.950
EFG46497.1
Aldehyde dehydrogenase (NAD) family protein; COG: COG1012; Pfam: PF01619,PF00171; InterPro: IPR015590; Belongs to the aldehyde dehydrogenase family.
   
 
 0.943
Your Current Organism:
Brevibacterium mcbrellneri
NCBI taxonomy Id: 585530
Other names: B. mcbrellneri ATCC 49030, Brevibacterium mcbrellneri ATCC 49030, Brevibacterium mcbrellneri str. ATCC 49030, Brevibacterium mcbrellneri strain ATCC 49030
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