node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EFG46462.1 | EFG48508.1 | HMPREF0183_2266 | HMPREF0183_0198 | 5'-nucleotidase, C-terminal domain protein; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | LPXTG-motif cell wall anchor domain protein; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | 0.947 |
EFG46462.1 | EFG48709.1 | HMPREF0183_2266 | HMPREF0183_0008 | 5'-nucleotidase, C-terminal domain protein; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | Endonuclease/exonuclease/phosphatase family protein; COG: COG2374; Pfam: PF04886,PF03372; InterPro: IPR005135. | 0.981 |
EFG46462.1 | add | HMPREF0183_2266 | HMPREF0183_2076 | 5'-nucleotidase, C-terminal domain protein; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | Adenosine deaminase; COG: COG1816; Pfam: PF00962; InterPro: IPR001365. | 0.940 |
EFG46462.1 | add-2 | HMPREF0183_2266 | HMPREF0183_2145 | 5'-nucleotidase, C-terminal domain protein; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | Adenosine deaminase; COG: COG1816; Pfam: PF00962; InterPro: IPR001365. | 0.948 |
EFG46462.1 | guaB-2 | HMPREF0183_2266 | HMPREF0183_0842 | 5'-nucleotidase, C-terminal domain protein; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.945 |
EFG46462.1 | guaB3 | HMPREF0183_2266 | HMPREF0183_0848 | 5'-nucleotidase, C-terminal domain protein; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | IMP dehydrogenase family protein; COG: COG0516; Pfam: PF00478; InterPro: IPR001093. | 0.893 |
EFG46462.1 | punA | HMPREF0183_2266 | HMPREF0183_0914 | 5'-nucleotidase, C-terminal domain protein; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | Purine nucleotide phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.941 |
EFG46462.1 | tdk | HMPREF0183_2266 | HMPREF0183_1952 | 5'-nucleotidase, C-terminal domain protein; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | Thymidine kinase; COG: COG1435; Pfam: PF00265; InterPro: IPR001267. | 0.886 |
EFG46462.1 | tmk | HMPREF0183_2266 | HMPREF0183_1232 | 5'-nucleotidase, C-terminal domain protein; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.737 |
EFG46462.1 | ushA | HMPREF0183_2266 | HMPREF0183_0858 | 5'-nucleotidase, C-terminal domain protein; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | LPXTG-motif cell wall anchor domain protein; COG: COG0737; Pfam: PF00149,PF02872,PF00746; InterPro: IPR006179. | 0.938 |
EFG48508.1 | EFG46462.1 | HMPREF0183_0198 | HMPREF0183_2266 | LPXTG-motif cell wall anchor domain protein; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | 5'-nucleotidase, C-terminal domain protein; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | 0.947 |
EFG48508.1 | EFG48709.1 | HMPREF0183_0198 | HMPREF0183_0008 | LPXTG-motif cell wall anchor domain protein; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | Endonuclease/exonuclease/phosphatase family protein; COG: COG2374; Pfam: PF04886,PF03372; InterPro: IPR005135. | 0.824 |
EFG48508.1 | add | HMPREF0183_0198 | HMPREF0183_2076 | LPXTG-motif cell wall anchor domain protein; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | Adenosine deaminase; COG: COG1816; Pfam: PF00962; InterPro: IPR001365. | 0.951 |
EFG48508.1 | add-2 | HMPREF0183_0198 | HMPREF0183_2145 | LPXTG-motif cell wall anchor domain protein; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | Adenosine deaminase; COG: COG1816; Pfam: PF00962; InterPro: IPR001365. | 0.940 |
EFG48508.1 | guaB-2 | HMPREF0183_0198 | HMPREF0183_0842 | LPXTG-motif cell wall anchor domain protein; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.919 |
EFG48508.1 | guaB3 | HMPREF0183_0198 | HMPREF0183_0848 | LPXTG-motif cell wall anchor domain protein; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | IMP dehydrogenase family protein; COG: COG0516; Pfam: PF00478; InterPro: IPR001093. | 0.687 |
EFG48508.1 | punA | HMPREF0183_0198 | HMPREF0183_0914 | LPXTG-motif cell wall anchor domain protein; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | Purine nucleotide phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.941 |
EFG48508.1 | tdk | HMPREF0183_0198 | HMPREF0183_1952 | LPXTG-motif cell wall anchor domain protein; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | Thymidine kinase; COG: COG1435; Pfam: PF00265; InterPro: IPR001267. | 0.866 |
EFG48508.1 | tmk | HMPREF0183_0198 | HMPREF0183_1232 | LPXTG-motif cell wall anchor domain protein; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.716 |
EFG48508.1 | ushA | HMPREF0183_0198 | HMPREF0183_0858 | LPXTG-motif cell wall anchor domain protein; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | LPXTG-motif cell wall anchor domain protein; COG: COG0737; Pfam: PF00149,PF02872,PF00746; InterPro: IPR006179. | 0.967 |