STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisC-2Histidinol-phosphate transaminase; COG: COG0079; Pfam: PF00155; InterPro: IPR005861; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (367 aa)    
Predicted Functional Partners:
hisB
Histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase; COG: COG0131; Pfam: PF00475; InterPro: IPR000807.
 
 0.997
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
 0.956
tyrA
Prephenate dehydrogenase; COG: COG0287; Pfam: PF02153,PF01842; InterPro: IPR003099.
  
 
 0.956
hisN
Histidinol-phosphate phosphatase HisN; COG: COG0483; Pfam: PF00459; InterPro: IPR011809.
  
 
 0.942
pheA
Prephenate dehydratase; COG: COG0077; Pfam: PF00800; InterPro: IPR001086.
 
 
 0.911
dadA
FAD dependent oxidoreductase; COG: COG0665; Pfam: PF01266; InterPro: IPR006076.
   
 
 0.886
hutH
Histidine ammonia-lyase; COG: COG2986; Pfam: PF00221; InterPro: IPR005921.
    
 0.868
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
 
 0.845
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
 
 0.835
ldhd
Putative glycolate oxidase, subunit GlcD; Cytochrome; COG: COG0277; Pfam: PF01565,PF02913; InterPro: IPR004113.
  
    0.780
Your Current Organism:
Brevibacterium mcbrellneri
NCBI taxonomy Id: 585530
Other names: B. mcbrellneri ATCC 49030, Brevibacterium mcbrellneri ATCC 49030, Brevibacterium mcbrellneri str. ATCC 49030, Brevibacterium mcbrellneri strain ATCC 49030
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