STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SDK18763.1Signal peptidase I; Belongs to the peptidase S26 family. (176 aa)    
Predicted Functional Partners:
SDK18714.1
Uncharacterized membrane protein YdjX, TVP38/TMEM64 family, SNARE-associated domain.
  
  
 0.790
secD
SecD/SecF fusion protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily.
  
  
 0.727
lepA
GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.
 
 
 0.697
SDJ75740.1
Regulator of sigma E protease.
 
  
 0.668
SDK18848.1
DNA helicase/exodeoxyribonuclease V, subunit A; ATP-dependent DNA helicase.
  
    0.641
trpA
Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
  
  
 0.623
rnhB
RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
 
    0.616
SDK18797.1
ATP-dependent helicase/nuclease subunit B; ATP-dependent DNA helicase.
       0.614
topA
DNA topoisomerase-1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.569
SDK18886.1
Uncharacterized protein.
       0.566
Your Current Organism:
Jeotgalicoccus halophilus
NCBI taxonomy Id: 586411
Other names: CGMCC 1.8911, J. halophilus, Jeotgalicoccus halophilus Liu et al. 2011, Jeotgalicoccus sp. C1-52, Jeotgalicoccus sp. YD-9, NBRC 105788, strain C1-52
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