STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BBBOND_0212220DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (856 aa)    
Predicted Functional Partners:
BBBOND_0101830
3'-5' exonuclease domain containing protein, putative.
  
 0.999
BBBOND_0211490
RMI1_N domain-containing protein.
    
 0.992
BBBOND_0211550
DNA repair endonuclease, putative.
    
 0.956
BBBOND_0100790
Uncharacterized protein.
    
 0.919
BBBOND_0211660
Conserved hypothetcial protein, putative.
    
 0.902
BBBOND_0200590
ATP-dependent DNA helicase, RecQ family protein, putative.
  
 0.865
BBBOND_0104790
ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.
  
 0.865
BBBOND_0102430
AAA_23 domain-containing protein.
  
 0.858
BBBOND_0302830
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
  
  
0.843
BBBOND_0101720
Replication protein A subunit.
   
 0.814
Your Current Organism:
Babesia bigemina
NCBI taxonomy Id: 5866
Other names: B. bigemina
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.