ENSMMDP00005011339 protein (Myripristis murdjan)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

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Databases

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[Homology]

Score

ENSMMDP00005011339

annotation not available (330 aa)

Predicted Functional Partners:

LOC115374146

0.700

ENSMMDP00005007228

0.636

ENSMMDP00005012905

0.636

ENSMMDP00005047012

0.636

LOC115364025

0.630

LOC115361531

0.611

LOC115359951

0.611

LOC115371676

0.611

ENSMMDP00005054988

0.611

LOC115375538

0.601

Your Current Organism:

Myripristis murdjan

NCBI taxonomy Id: 586833
Other names: M. murdjan, Ostichthys murdjan, Perca murdjan, Sciaena murdjan, pinecone soldierfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSMMDP00005007228	ENSMMDP00005011339	ENSMMDP00005007228	ENSMMDP00005011339	annotation not available	annotation not available	0.636
ENSMMDP00005007228	ENSMMDP00005054988	ENSMMDP00005007228	ENSMMDP00005054988	annotation not available	Guanine nucleotide binding protein (G protein), beta polypeptide 4b.	0.882
ENSMMDP00005007228	LOC115359951	ENSMMDP00005007228	ENSMMDP00005006354	annotation not available	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1-like.	0.882
ENSMMDP00005007228	LOC115361531	ENSMMDP00005007228	ENSMMDP00005000590	annotation not available	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1.	0.882
ENSMMDP00005007228	LOC115364025	ENSMMDP00005007228	ENSMMDP00005036447	annotation not available	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13-like.	0.935
ENSMMDP00005007228	LOC115371676	ENSMMDP00005007228	ENSMMDP00005037069	annotation not available	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2.	0.882
ENSMMDP00005007228	LOC115374146	ENSMMDP00005007228	ENSMMDP00005020201	annotation not available	Uncharacterized LOC115374146.	0.892
ENSMMDP00005007228	LOC115375538	ENSMMDP00005007228	ENSMMDP00005022622	annotation not available	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12.	0.835
ENSMMDP00005011339	ENSMMDP00005007228	ENSMMDP00005011339	ENSMMDP00005007228	annotation not available	annotation not available	0.636
ENSMMDP00005011339	ENSMMDP00005012905	ENSMMDP00005011339	ENSMMDP00005012905	annotation not available	annotation not available	0.636
ENSMMDP00005011339	ENSMMDP00005047012	ENSMMDP00005011339	ENSMMDP00005047012	annotation not available	annotation not available	0.636
ENSMMDP00005011339	ENSMMDP00005054988	ENSMMDP00005011339	ENSMMDP00005054988	annotation not available	Guanine nucleotide binding protein (G protein), beta polypeptide 4b.	0.611
ENSMMDP00005011339	LOC115359951	ENSMMDP00005011339	ENSMMDP00005006354	annotation not available	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1-like.	0.611
ENSMMDP00005011339	LOC115361531	ENSMMDP00005011339	ENSMMDP00005000590	annotation not available	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1.	0.611
ENSMMDP00005011339	LOC115364025	ENSMMDP00005011339	ENSMMDP00005036447	annotation not available	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13-like.	0.630
ENSMMDP00005011339	LOC115371676	ENSMMDP00005011339	ENSMMDP00005037069	annotation not available	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2.	0.611
ENSMMDP00005011339	LOC115374146	ENSMMDP00005011339	ENSMMDP00005020201	annotation not available	Uncharacterized LOC115374146.	0.700
ENSMMDP00005011339	LOC115375538	ENSMMDP00005011339	ENSMMDP00005022622	annotation not available	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12.	0.601
ENSMMDP00005012905	ENSMMDP00005011339	ENSMMDP00005012905	ENSMMDP00005011339	annotation not available	annotation not available	0.636
ENSMMDP00005012905	ENSMMDP00005054988	ENSMMDP00005012905	ENSMMDP00005054988	annotation not available	Guanine nucleotide binding protein (G protein), beta polypeptide 4b.	0.882

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.818

expected number of edges:

20

PPI enrichment p-value:

0.0113

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019470

4-hydroxyproline catabolic process

2 of 2

2.56

1.03

0.0133

GO:0046653

Tetrahydrofolate metabolic process

3 of 18

1.78

0.95

0.0133

GO:1901606

Alpha-amino acid catabolic process

3 of 28

1.59

0.9

0.0133

GO:0006575

Cellular modified amino acid metabolic process

5 of 102

1.25

0.87

0.0067

GO:0046416

D-amino acid metabolic process

2 of 6

2.08

0.87

0.0231

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008115

Sarcosine oxidase activity

3 of 9

2.08

1.58

0.00085

GO:0016645

Oxidoreductase activity, acting on the CH-NH group of donors

4 of 33

1.64

1.42

0.00074

GO:0016491

Oxidoreductase activity

9 of 515

0.8

0.69

0.00034

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1927

GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1, and Sarcosine oxidase, delta subunit family

4 of 24

1.78

1.79

0.00013

CL:1922

Mixed, incl. GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1, and NADH:flavin oxidoreductase / NADH oxidase family

5 of 50

1.56

1.63

0.00011

CL:1929

FAD dependent oxidoreductase central domain, and Sarcosine oxidase activity

3 of 18

1.78

1.3

0.0022

CL:1699

Mixed, incl. Carbon metabolism, and Oxidoreductase activity, acting on the CH-NH group of donors

7 of 181

1.15

0.00011

CL:5479

Mixed, incl. Alkylhydroperoxidase AhpD core, and EF-hand, calcium binding motif

2 of 6

2.08

0.92

0.0187

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00472

D-Arginine and D-ornithine metabolism

2 of 3

2.39

1.17

0.0071

map00330

Arginine and proline metabolism

3 of 57

1.28

0.73

0.0203

map01100

Metabolic pathways

11 of 1641

0.39

0.31

0.0071

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005737

Cytoplasm

10 of 1255

0.46

0.34

0.0135

GOCC:0005622

Intracellular

11 of 1613

0.39

0.3

0.0135

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07992

Pyridine nucleotide-disulphide oxidoreductase

4 of 16

1.96

1.99

8.26e-05

PF13510

2Fe-2S iron-sulfur cluster binding domain

3 of 7

2.19

1.71

0.00052

PF04324

BFD-like [2Fe-2S] binding domain

2 of 2

2.56

1.27

0.0047

PF08669

Glycine cleavage T-protein C-terminal barrel domain

3 of 19

1.76

1.19

0.0038

PF01571

Aminomethyltransferase folate-binding domain

3 of 18

1.78

1.19

0.0038

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR041117

SoxA, A3 domain

5 of 5

2.56

4.02

1.96e-08

IPR041854

BFD-like [2Fe-2S]-binding domain superfamily

4 of 4

2.56

3.17

1.04e-06

IPR036188

FAD/NAD(P)-binding domain superfamily

7 of 80

1.5

2.15

3.98e-07

IPR042204

2Fe-2S iron-sulfur cluster binding domain, N-terminal

3 of 5

2.34

1.91

0.00025

IPR023753

FAD/NAD(P)-binding domain

4 of 24

1.78

1.7

0.00022

(more ...)

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