cfl2 protein (Myripristis murdjan) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

cfl2

Cofilin 2. (173 aa)

Predicted Functional Partners:

ENSMMDP00005012147

0.968

limk2

0.962

ENSMMDP00005002231

0.960

LOC115366791

0.937

LOC115364875

0.937

actb

0.937

ENSMMDP00005004135

0.926

ssh1

0.926

ENSMMDP00005007252

0.925

LOC115370390

0.925

Your Current Organism:

Myripristis murdjan

NCBI taxonomy Id: 586833
Other names: M. murdjan, Ostichthys murdjan, Perca murdjan, Sciaena murdjan, pinecone soldierfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSMMDP00005002231	ENSMMDP00005004135	ENSMMDP00005002231	ENSMMDP00005004135	LIM domain kinase 1b.	Si:ch211-203d1.3.	0.553
ENSMMDP00005002231	ENSMMDP00005007252	ENSMMDP00005002231	ENSMMDP00005007252	LIM domain kinase 1b.	Slingshot protein phosphatase 2b.	0.553
ENSMMDP00005002231	ENSMMDP00005012147	ENSMMDP00005002231	ENSMMDP00005012147	LIM domain kinase 1b.	LIM domain kinase 1a.	0.836
ENSMMDP00005002231	LOC115370390	ENSMMDP00005002231	ENSMMDP00005025118	LIM domain kinase 1b.	Protein phosphatase Slingshot homolog 2-like.	0.553
ENSMMDP00005002231	cfl2	ENSMMDP00005002231	ENSMMDP00005016325	LIM domain kinase 1b.	Cofilin 2.	0.960
ENSMMDP00005002231	limk2	ENSMMDP00005002231	ENSMMDP00005045760	LIM domain kinase 1b.	LIM domain kinase 2.	0.838
ENSMMDP00005002231	ssh1	ENSMMDP00005002231	ENSMMDP00005039412	LIM domain kinase 1b.	Slingshot protein phosphatase 1.	0.553
ENSMMDP00005004135	ENSMMDP00005002231	ENSMMDP00005004135	ENSMMDP00005002231	Si:ch211-203d1.3.	LIM domain kinase 1b.	0.553
ENSMMDP00005004135	ENSMMDP00005007252	ENSMMDP00005004135	ENSMMDP00005007252	Si:ch211-203d1.3.	Slingshot protein phosphatase 2b.	0.819
ENSMMDP00005004135	ENSMMDP00005012147	ENSMMDP00005004135	ENSMMDP00005012147	Si:ch211-203d1.3.	LIM domain kinase 1a.	0.553
ENSMMDP00005004135	LOC115370390	ENSMMDP00005004135	ENSMMDP00005025118	Si:ch211-203d1.3.	Protein phosphatase Slingshot homolog 2-like.	0.817
ENSMMDP00005004135	cfl2	ENSMMDP00005004135	ENSMMDP00005016325	Si:ch211-203d1.3.	Cofilin 2.	0.926
ENSMMDP00005004135	limk2	ENSMMDP00005004135	ENSMMDP00005045760	Si:ch211-203d1.3.	LIM domain kinase 2.	0.553
ENSMMDP00005004135	ssh1	ENSMMDP00005004135	ENSMMDP00005039412	Si:ch211-203d1.3.	Slingshot protein phosphatase 1.	0.838
ENSMMDP00005007252	ENSMMDP00005002231	ENSMMDP00005007252	ENSMMDP00005002231	Slingshot protein phosphatase 2b.	LIM domain kinase 1b.	0.553
ENSMMDP00005007252	ENSMMDP00005004135	ENSMMDP00005007252	ENSMMDP00005004135	Slingshot protein phosphatase 2b.	Si:ch211-203d1.3.	0.819
ENSMMDP00005007252	ENSMMDP00005012147	ENSMMDP00005007252	ENSMMDP00005012147	Slingshot protein phosphatase 2b.	LIM domain kinase 1a.	0.553
ENSMMDP00005007252	cfl2	ENSMMDP00005007252	ENSMMDP00005016325	Slingshot protein phosphatase 2b.	Cofilin 2.	0.925
ENSMMDP00005007252	limk2	ENSMMDP00005007252	ENSMMDP00005045760	Slingshot protein phosphatase 2b.	LIM domain kinase 2.	0.553
ENSMMDP00005007252	ssh1	ENSMMDP00005007252	ENSMMDP00005039412	Slingshot protein phosphatase 2b.	Slingshot protein phosphatase 1.	0.837

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.875

expected number of edges:

11

PPI enrichment p-value:

4.94e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009252

Peptidoglycan biosynthetic process

8 of 38

1.96

4.42

8.65e-12

GO:0071555

Cell wall organization

4 of 26

1.83

2.07

2.98e-05

GO:0008360

Regulation of cell shape

4 of 26

1.83

2.07

2.98e-05

GO:0051301

Cell division

3 of 44

1.47

0.99

0.0063

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008955

Peptidoglycan glycosyltransferase activity

5 of 7

2.49

4.05

1.40e-08

GO:0008658

Penicillin binding

4 of 6

2.46

3.21

7.03e-07

GO:0009002

Serine-type D-Ala-D-Ala carboxypeptidase activity

3 of 5

2.42

2.34

3.71e-05

GO:0016757

Glycosyltransferase activity

6 of 61

1.63

2.33

7.03e-07

GO:0004180

Carboxypeptidase activity

4 of 19

1.96

2.32

1.32e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1359

Mixed, incl. Peptidoglycan biosynthesis, and Cell division

11 of 46

2.02

6.54

2.68e-19

CL:1363

Mixed, incl. Peptidoglycan biosynthesis, and Cell division site

9 of 33

2.07

5.85

1.83e-15

CL:1416

Peptidoglycan glycosyltransferase activity, and Peptidoglycan muralytic activity

4 of 5

2.54

3.48

2.33e-07

CL:1365

Mixed, incl. Cell shape, and Cell division site

5 of 23

1.98

3.01

2.35e-07

CL:1398

Mixed, incl. Cell cycle protein, and Cell morphogenesis

2 of 5

2.24

1.07

0.0102

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00550

Peptidoglycan biosynthesis

6 of 33

1.9

3.33

1.15e-08

map01501

beta-Lactam resistance

4 of 121

1.16

0.79

0.0083

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032153

Cell division site

3 of 9

2.16

1.68

0.00059

GOCC:0005618

Cell wall

3 of 21

1.79

1.26

0.0027

GOCC:0071944

Cell periphery

7 of 713

0.63

0.39

0.0319

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0961

Cell wall biogenesis/degradation

3 of 16

1.91

1.38

0.0018

KW-0133

Cell shape

3 of 16

1.91

1.38

0.0018

KW-0997

Cell inner membrane

3 of 42

1.49

0.94

0.0087

KW-0573

Peptidoglycan synthesis

2 of 15

1.76

0.87

0.0198

KW-0328

Glycosyltransferase

2 of 22

1.6

0.73

0.0348

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00905

Penicillin binding protein transpeptidase domain

4 of 6

2.46

2.98

2.11e-06

PF03717

Penicillin-binding Protein dimerisation domain

2 of 2

2.64

1.11

0.0097

PF01098

Cell cycle protein

2 of 2

2.64

1.11

0.0097

PF00912

Transglycosylase

2 of 4

2.34

1.04

0.0120

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001460

Penicillin-binding protein, transpeptidase

4 of 6

2.46

2.92

2.73e-06

IPR012338

Beta-lactamase/transpeptidase-like

5 of 18

2.08

2.84

1.26e-06

IPR036138

Penicillin-binding protein, dimerisation domain superfamily

2 of 2

2.64

0.98

0.0167

IPR005311

Penicillin-binding protein, dimerisation domain

2 of 2

2.64

0.98

0.0167

IPR001182

Probable peptidoglycan glycosyltransferase FtsW/RodA

2 of 2

2.64

0.98

0.0167

(more ...)

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