lsamp protein (Myripristis murdjan) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

lsamp

Limbic system associated membrane protein. (337 aa)

Predicted Functional Partners:

ENSMMDP00005048556

0.604

PTK7

0.515

ENSMMDP00005005399

0.503

ENSMMDP00005036137

0.503

ENSMMDP00005022968

0.498

SLITRK1

0.490

ENSMMDP00005043900

0.488

PTPRM

0.480

ENSMMDP00005042950

0.478

ENSMMDP00005042976

0.478

Your Current Organism:

Myripristis murdjan

NCBI taxonomy Id: 586833
Other names: M. murdjan, Ostichthys murdjan, Perca murdjan, Sciaena murdjan, pinecone soldierfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSMMDP00005005399	ENSMMDP00005036137	ENSMMDP00005005399	ENSMMDP00005036137	annotation not available	annotation not available	0.482
ENSMMDP00005005399	ENSMMDP00005042950	ENSMMDP00005005399	ENSMMDP00005042950	annotation not available	Hyaluronan binding protein 2.	0.910
ENSMMDP00005005399	ENSMMDP00005042976	ENSMMDP00005005399	ENSMMDP00005042976	annotation not available	Hyaluronan binding protein 2.	0.910
ENSMMDP00005005399	ENSMMDP00005048556	ENSMMDP00005005399	ENSMMDP00005048556	annotation not available	IgLON family member 5.	0.503
ENSMMDP00005005399	PTK7	ENSMMDP00005005399	ENSMMDP00005054131	annotation not available	Protein tyrosine kinase 7 (inactive).	0.721
ENSMMDP00005005399	PTPRM	ENSMMDP00005005399	ENSMMDP00005051785	annotation not available	Protein tyrosine phosphatase receptor type M.	0.554
ENSMMDP00005005399	lsamp	ENSMMDP00005005399	ENSMMDP00005025027	annotation not available	Limbic system associated membrane protein.	0.503
ENSMMDP00005022968	ENSMMDP00005048556	ENSMMDP00005022968	ENSMMDP00005048556	annotation not available	IgLON family member 5.	0.498
ENSMMDP00005022968	lsamp	ENSMMDP00005022968	ENSMMDP00005025027	annotation not available	Limbic system associated membrane protein.	0.498
ENSMMDP00005036137	ENSMMDP00005005399	ENSMMDP00005036137	ENSMMDP00005005399	annotation not available	annotation not available	0.482
ENSMMDP00005036137	ENSMMDP00005042950	ENSMMDP00005036137	ENSMMDP00005042950	annotation not available	Hyaluronan binding protein 2.	0.910
ENSMMDP00005036137	ENSMMDP00005042976	ENSMMDP00005036137	ENSMMDP00005042976	annotation not available	Hyaluronan binding protein 2.	0.910
ENSMMDP00005036137	ENSMMDP00005048556	ENSMMDP00005036137	ENSMMDP00005048556	annotation not available	IgLON family member 5.	0.503
ENSMMDP00005036137	PTK7	ENSMMDP00005036137	ENSMMDP00005054131	annotation not available	Protein tyrosine kinase 7 (inactive).	0.721
ENSMMDP00005036137	PTPRM	ENSMMDP00005036137	ENSMMDP00005051785	annotation not available	Protein tyrosine phosphatase receptor type M.	0.525
ENSMMDP00005036137	lsamp	ENSMMDP00005036137	ENSMMDP00005025027	annotation not available	Limbic system associated membrane protein.	0.503
ENSMMDP00005042950	ENSMMDP00005005399	ENSMMDP00005042950	ENSMMDP00005005399	Hyaluronan binding protein 2.	annotation not available	0.910
ENSMMDP00005042950	ENSMMDP00005036137	ENSMMDP00005042950	ENSMMDP00005036137	Hyaluronan binding protein 2.	annotation not available	0.910
ENSMMDP00005042950	ENSMMDP00005042976	ENSMMDP00005042950	ENSMMDP00005042976	Hyaluronan binding protein 2.	Hyaluronan binding protein 2.	0.521
ENSMMDP00005042950	ENSMMDP00005048556	ENSMMDP00005042950	ENSMMDP00005048556	Hyaluronan binding protein 2.	IgLON family member 5.	0.478

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

42

average node degree:

7.64

avg. local clustering coefficient:

0.908

expected number of edges:

10

PPI enrichment p-value:

9.44e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006011

UDP-glucose metabolic process

2 of 2

2.27

0.91

0.0211

GO:0009225

Nucleotide-sugar metabolic process

3 of 12

1.66

0.89

0.0160

GO:0005975

Carbohydrate metabolic process

8 of 163

0.96

0.87

0.00026

GO:0000271

Polysaccharide biosynthetic process

4 of 35

1.32

0.78

0.0160

GO:0005978

Glycogen biosynthetic process

2 of 4

1.97

0.78

0.0331

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016779

Nucleotidyltransferase activity

5 of 42

1.34

1.14

0.0012

GO:0008878

glucose-1-phosphate adenylyltransferase activity

2 of 2

2.27

0.75

0.0421

GO:0003983

UTP:glucose-1-phosphate uridylyltransferase activity

2 of 2

2.27

0.75

0.0421

GO:0004645

1,4-alpha-oligoglucan phosphorylase activity

2 of 3

2.09

0.74

0.0421

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031470

Carboxysome

2 of 2

2.27

0.98

0.0154

GO:0045121

Membrane raft

2 of 5

1.87

0.91

0.0178

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2250

Starch and sucrose metabolism, and Alpha-amylase domain

6 of 24

1.66

2.32

1.22e-06

CL:2282

Glycogen metabolic process

3 of 5

2.04

1.71

0.00043

CL:2034

Mixed, incl. Carbohydrate transport, and Microbial metabolism in diverse environments

7 of 132

0.99

0.94

0.00014

CL:2032

Carbohydrate transport, and Carbohydrate metabolic process

8 of 166

0.95

0.91

7.39e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lagl00500

Starch and sucrose metabolism

7 of 26

1.7

3.01

4.31e-09

lagl00520

Amino sugar and nucleotide sugar metabolism

6 of 26

1.63

2.48

1.84e-07

lagl00052

Galactose metabolism

4 of 10

1.87

2.23

1.38e-05

lagl00541

O-Antigen nucleotide sugar biosynthesis

4 of 11

1.83

2.19

1.41e-05

lagl00040

Pentose and glucuronate interconversions

2 of 3

2.09

1.29

0.0035

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0010170

glucose-1-phosphate adenylyltransferase complex

2 of 2

2.27

0.8

0.0331

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0548

Nucleotidyltransferase

5 of 26

1.55

1.73

4.38e-05

KW-0119

Carbohydrate metabolism

3 of 14

1.6

1.03

0.0066

KW-0808

Transferase

7 of 240

0.73

0.52

0.0066

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12804

MobA-like NTP transferase domain

4 of 5

2.17

2.39

1.90e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005835

Nucleotidyl transferase domain

5 of 5

2.27

3.26

3.06e-07

IPR029044

Nucleotide-diphospho-sugar transferases

5 of 21

1.64

1.85

3.84e-05

IPR011832

Glucose-1-phosphate adenylyltransferase, GlgD subunit

2 of 2

2.27

0.76

0.0411

IPR011831

Glucose-1-phosphate adenylyltransferase

2 of 2

2.27

0.76

0.0411

IPR005771

UTP--glucose-1-phosphate uridylyltransferase, bacterial/archaeal-type

2 of 2

2.27

0.76

0.0411

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