rfxap protein (Myripristis murdjan) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

rfxap

Regulatory factor X associated protein. (214 aa)

Predicted Functional Partners:

rfxank

0.976

ankra2

0.958

ENSMMDP00005000570

0.926

ENSMMDP00005009793

0.890

ENSMMDP00005027891

0.890

rfx4

0.882

ENSMMDP00005031778

0.870

ENSMMDP00005000449

0.869

ENSMMDP00005003084

0.869

ENSMMDP00005035309

0.869

Your Current Organism:

Myripristis murdjan

NCBI taxonomy Id: 586833
Other names: M. murdjan, Ostichthys murdjan, Perca murdjan, Sciaena murdjan, pinecone soldierfish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSMMDP00005000449	ankra2	ENSMMDP00005000449	ENSMMDP00005046951	Regulatory factor X, 1a (influences HLA class II expression).	Ankyrin repeat family A member 2.	0.718
ENSMMDP00005000449	rfxank	ENSMMDP00005000449	ENSMMDP00005032268	Regulatory factor X, 1a (influences HLA class II expression).	Regulatory factor X associated ankyrin containing protein.	0.757
ENSMMDP00005000449	rfxap	ENSMMDP00005000449	ENSMMDP00005025818	Regulatory factor X, 1a (influences HLA class II expression).	Regulatory factor X associated protein.	0.869
ENSMMDP00005000570	rfxank	ENSMMDP00005000570	ENSMMDP00005032268	Class II, major histocompatibility complex, transactivator.	Regulatory factor X associated ankyrin containing protein.	0.952
ENSMMDP00005000570	rfxap	ENSMMDP00005000570	ENSMMDP00005025818	Class II, major histocompatibility complex, transactivator.	Regulatory factor X associated protein.	0.926
ENSMMDP00005003084	ankra2	ENSMMDP00005003084	ENSMMDP00005046951	Regulatory factor X, 2 (influences HLA class II expression).	Ankyrin repeat family A member 2.	0.718
ENSMMDP00005003084	rfxank	ENSMMDP00005003084	ENSMMDP00005032268	Regulatory factor X, 2 (influences HLA class II expression).	Regulatory factor X associated ankyrin containing protein.	0.757
ENSMMDP00005003084	rfxap	ENSMMDP00005003084	ENSMMDP00005025818	Regulatory factor X, 2 (influences HLA class II expression).	Regulatory factor X associated protein.	0.869
ENSMMDP00005009793	ankra2	ENSMMDP00005009793	ENSMMDP00005046951	Regulatory factor X7b.	Ankyrin repeat family A member 2.	0.729
ENSMMDP00005009793	rfxank	ENSMMDP00005009793	ENSMMDP00005032268	Regulatory factor X7b.	Regulatory factor X associated ankyrin containing protein.	0.795
ENSMMDP00005009793	rfxap	ENSMMDP00005009793	ENSMMDP00005025818	Regulatory factor X7b.	Regulatory factor X associated protein.	0.890
ENSMMDP00005027891	ankra2	ENSMMDP00005027891	ENSMMDP00005046951	Regulatory factor X7a.	Ankyrin repeat family A member 2.	0.727
ENSMMDP00005027891	rfxank	ENSMMDP00005027891	ENSMMDP00005032268	Regulatory factor X7a.	Regulatory factor X associated ankyrin containing protein.	0.795
ENSMMDP00005027891	rfxap	ENSMMDP00005027891	ENSMMDP00005025818	Regulatory factor X7a.	Regulatory factor X associated protein.	0.890
ENSMMDP00005031778	ankra2	ENSMMDP00005031778	ENSMMDP00005046951	Regulatory factor X, 6.	Ankyrin repeat family A member 2.	0.718
ENSMMDP00005031778	rfxank	ENSMMDP00005031778	ENSMMDP00005032268	Regulatory factor X, 6.	Regulatory factor X associated ankyrin containing protein.	0.763
ENSMMDP00005031778	rfxap	ENSMMDP00005031778	ENSMMDP00005025818	Regulatory factor X, 6.	Regulatory factor X associated protein.	0.870
ENSMMDP00005035309	ankra2	ENSMMDP00005035309	ENSMMDP00005046951	Regulatory factor X, 3 (influences HLA class II expression).	Ankyrin repeat family A member 2.	0.718
ENSMMDP00005035309	rfxank	ENSMMDP00005035309	ENSMMDP00005032268	Regulatory factor X, 3 (influences HLA class II expression).	Regulatory factor X associated ankyrin containing protein.	0.757
ENSMMDP00005035309	rfxap	ENSMMDP00005035309	ENSMMDP00005025818	Regulatory factor X, 3 (influences HLA class II expression).	Regulatory factor X associated protein.	0.869

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

52

average node degree:

9.45

avg. local clustering coefficient:

0.958

expected number of edges:

20

PPI enrichment p-value:

2.86e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007165

Signal transduction

6 of 62

1.51

1.91

6.21e-06

GO:0000160

Phosphorelay signal transduction system

5 of 52

1.51

1.66

5.65e-05

GO:0050794

Regulation of cellular process

9 of 253

1.08

1.24

2.38e-06

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004673

Protein histidine kinase activity

5 of 25

1.83

2.27

8.43e-06

GO:0000155

Phosphorelay sensor kinase activity

4 of 24

1.75

1.79

0.00011

GO:0016772

Transferase activity, transferring phosphorus-containing groups

7 of 171

1.14

1.22

2.82e-05

GO:0016740

Transferase activity

9 of 591

0.71

0.61

0.00028

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

7 of 579

0.61

0.36

0.0471

GO:0016021

Integral component of membrane

8 of 769

0.54

0.33

0.0471

GO:0016020

Membrane

9 of 1176

0.41

0.28

0.0471

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2148

Phosphorelay signal transduction system, and RNA polymerase sigma factor 54 interaction domain

11 of 41

1.96

6.07

1.09e-18

CL:2155

Mixed, incl. PAS domain, and Phosphoric diester hydrolase activity

8 of 21

2.11

5.5

6.46e-14

CL:2161

PAS-associated, C-terminal, and Bacterial chemotaxis

6 of 10

2.31

4.88

6.39e-11

CL:2163

Diguanylate cyclase, and Regulation of signaling

3 of 5

2.31

2.21

5.90e-05

CL:2215

Sigma-54 interaction domain, ATP-binding site 1, and PAS fold

3 of 7

2.16

2.01

0.00012

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

10 of 277

1.08

1.42

8.29e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

4 of 74

1.26

0.79

0.0122

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001610

PAC motif

4 of 8

2.23

2.3

3.24e-05

IPR035965

PAS domain superfamily

4 of 10

2.13

2.26

3.27e-05

IPR000014

PAS domain

4 of 10

2.13

2.26

3.27e-05

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

4 of 17

1.9

1.92

9.67e-05

IPR005467

Histidine kinase domain

4 of 20

1.83

1.81

0.00014

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

4 of 9

2.17

2.71

3.74e-06

SM00091

PAS domain

4 of 11

2.09

2.64

3.74e-06

SM00388

His Kinase A (phosphoacceptor) domain

4 of 17

1.9

2.31

1.03e-05

SM00387

Histidine kinase-like ATPases

4 of 22

1.79

2.1

1.92e-05

SM00065

Domain present in phytochromes and cGMP-specific phosphodiesterases.

2 of 5

2.13

1.25

0.0042

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (22%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About