acrZ protein (Providencia rettgeri) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

acrZ

Multidrug efflux pump accessory protein AcrZ; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export. (50 aa)

Predicted Functional Partners:

modE

0.579

tolC

0.561

bepE_1

0.491

acrB_1

0.491

acrB_2

0.491

bepE_2

0.491

Your Current Organism:

Providencia rettgeri

NCBI taxonomy Id: 587
Other names: ATCC 29944, Bacterium rettgeri, CCUG 14804, CIP 103182, DSM 4542, LMG 3259, LMG:3259, NCTC 11801, P. rettgeri, Proteus rettgeri, Shigella rettgeri

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
acrB_1	acrZ	RB151_004840	RB151_011500	Multidrug efflux pump subunit AcrB.	Multidrug efflux pump accessory protein AcrZ; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.	0.491
acrB_1	bepE_1	RB151_004840	RB151_004830	Multidrug efflux pump subunit AcrB.	Efflux pump membrane transporter BepE; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.	0.992
acrB_1	tolC	RB151_004840	RB151_036110	Multidrug efflux pump subunit AcrB.	Outer membrane protein TolC precursor.	0.419
acrB_2	acrZ	RB151_033900	RB151_011500	Multidrug efflux pump subunit AcrB.	Multidrug efflux pump accessory protein AcrZ; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.	0.491
acrB_2	tolC	RB151_033900	RB151_036110	Multidrug efflux pump subunit AcrB.	Outer membrane protein TolC precursor.	0.959
acrZ	acrB_1	RB151_011500	RB151_004840	Multidrug efflux pump accessory protein AcrZ; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.	Multidrug efflux pump subunit AcrB.	0.491
acrZ	acrB_2	RB151_011500	RB151_033900	Multidrug efflux pump accessory protein AcrZ; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.	Multidrug efflux pump subunit AcrB.	0.491
acrZ	bepE_1	RB151_011500	RB151_004830	Multidrug efflux pump accessory protein AcrZ; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.	Efflux pump membrane transporter BepE; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.	0.491
acrZ	bepE_2	RB151_011500	RB151_040620	Multidrug efflux pump accessory protein AcrZ; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.	Efflux pump membrane transporter BepE.	0.491
acrZ	modE	RB151_011500	RB151_011490	Multidrug efflux pump accessory protein AcrZ; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.	Transcriptional regulator ModE.	0.579
acrZ	tolC	RB151_011500	RB151_036110	Multidrug efflux pump accessory protein AcrZ; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.	Outer membrane protein TolC precursor.	0.561
bepE_1	acrB_1	RB151_004830	RB151_004840	Efflux pump membrane transporter BepE; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.	Multidrug efflux pump subunit AcrB.	0.992
bepE_1	acrZ	RB151_004830	RB151_011500	Efflux pump membrane transporter BepE; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.	Multidrug efflux pump accessory protein AcrZ; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.	0.491
bepE_1	tolC	RB151_004830	RB151_036110	Efflux pump membrane transporter BepE; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.	Outer membrane protein TolC precursor.	0.432
bepE_2	acrZ	RB151_040620	RB151_011500	Efflux pump membrane transporter BepE.	Multidrug efflux pump accessory protein AcrZ; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.	0.491
modE	acrZ	RB151_011490	RB151_011500	Transcriptional regulator ModE.	Multidrug efflux pump accessory protein AcrZ; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.	0.579
tolC	acrB_1	RB151_036110	RB151_004840	Outer membrane protein TolC precursor.	Multidrug efflux pump subunit AcrB.	0.419
tolC	acrB_2	RB151_036110	RB151_033900	Outer membrane protein TolC precursor.	Multidrug efflux pump subunit AcrB.	0.959
tolC	acrZ	RB151_036110	RB151_011500	Outer membrane protein TolC precursor.	Multidrug efflux pump accessory protein AcrZ; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.	0.561
tolC	bepE_1	RB151_036110	RB151_004830	Outer membrane protein TolC precursor.	Efflux pump membrane transporter BepE; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.	0.432

Server load: low (22%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2025

Credits

Access

Info

About