STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
macA_1Macrolide export protein MacA; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (368 aa)    
Predicted Functional Partners:
macB_1
Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
 
 
 0.996
macB_2
Macrolide export ATP-binding/permease protein MacB.
 
 
 0.991
acrB_2
Multidrug efflux pump subunit AcrB.
 
 
 0.675
mdtK
Multidrug resistance protein MdtK; Multidrug efflux pump that functions probably as a Na(+)/drug antiporter; Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily.
      
 0.652
arpC
Antibiotic efflux pump outer membrane protein ArpC precursor.
 
 
 0.633
bepE_2
Efflux pump membrane transporter BepE.
 
 
 0.620
bepE_1
Efflux pump membrane transporter BepE; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
 
 
 0.552
acrB_1
Multidrug efflux pump subunit AcrB.
 
 
 0.533
recF_2
DNA replication and repair protein RecF.
 
     0.521
cusC
Cation efflux system protein CusC precursor.
 
 
 0.486
Your Current Organism:
Providencia rettgeri
NCBI taxonomy Id: 587
Other names: ATCC 29944, Bacterium rettgeri, CCUG 14804, CIP 103182, DSM 4542, LMG 3259, LMG:3259, NCTC 11801, P. rettgeri, Proteus rettgeri, Shigella rettgeri
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