| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| dus | purR_2 | RB151_005360 | RB151_019590 | Putative tRNA-dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. | HTH-type transcriptional repressor PurR; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. | 0.523 |
| hypA | purR_2 | RB151_036670 | RB151_019590 | Hydrogenase nickel incorporation protein HybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | HTH-type transcriptional repressor PurR; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. | 0.423 |
| hypA | sapB | RB151_036670 | RB151_019760 | Hydrogenase nickel incorporation protein HybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | Peptide transport system permease protein SapB. | 0.473 |
| hypA | trpC | RB151_036670 | RB151_023430 | Hydrogenase nickel incorporation protein HybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | Tryptophan biosynthesis protein TrpCF. | 0.661 |
| purR_2 | dus | RB151_019590 | RB151_005360 | HTH-type transcriptional repressor PurR; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. | Putative tRNA-dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. | 0.523 |
| purR_2 | hypA | RB151_019590 | RB151_036670 | HTH-type transcriptional repressor PurR; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. | Hydrogenase nickel incorporation protein HybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | 0.423 |
| purR_2 | sapB | RB151_019590 | RB151_019760 | HTH-type transcriptional repressor PurR; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. | Peptide transport system permease protein SapB. | 0.648 |
| purR_2 | sodB | RB151_019590 | RB151_019600 | HTH-type transcriptional repressor PurR; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. | Superoxide dismutase [Fe]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. | 0.478 |
| purR_2 | trpC | RB151_019590 | RB151_023430 | HTH-type transcriptional repressor PurR; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. | Tryptophan biosynthesis protein TrpCF. | 0.493 |
| sapB | hypA | RB151_019760 | RB151_036670 | Peptide transport system permease protein SapB. | Hydrogenase nickel incorporation protein HybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | 0.473 |
| sapB | purR_2 | RB151_019760 | RB151_019590 | Peptide transport system permease protein SapB. | HTH-type transcriptional repressor PurR; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. | 0.648 |
| sapB | trpC | RB151_019760 | RB151_023430 | Peptide transport system permease protein SapB. | Tryptophan biosynthesis protein TrpCF. | 0.715 |
| sodB | purR_2 | RB151_019600 | RB151_019590 | Superoxide dismutase [Fe]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. | HTH-type transcriptional repressor PurR; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. | 0.478 |
| trpC | hypA | RB151_023430 | RB151_036670 | Tryptophan biosynthesis protein TrpCF. | Hydrogenase nickel incorporation protein HybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | 0.661 |
| trpC | purR_2 | RB151_023430 | RB151_019590 | Tryptophan biosynthesis protein TrpCF. | HTH-type transcriptional repressor PurR; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. | 0.493 |
| trpC | sapB | RB151_023430 | RB151_019760 | Tryptophan biosynthesis protein TrpCF. | Peptide transport system permease protein SapB. | 0.715 |