STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rseAAnti-sigma-E factor RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish de [...] (209 aa)    
Predicted Functional Partners:
rseB
Sigma-E factor regulatory protein RseB precursor.
 
 
 0.998
rpoE
ECF RNA polymerase sigma-E factor; Belongs to the sigma-70 factor family. ECF subfamily.
 
 
 0.989
fecI
Putative RNA polymerase sigma factor FecI; Belongs to the sigma-70 factor family. ECF subfamily.
  
 
 0.908
rseC
SoxR reducing system protein RseC.
 
  
 0.901
glpG
Rhomboid protease GlpG; Rhomboid-type serine protease that catalyzes intramembrane proteolysis.
  
   
 0.859
degS
Serine endoprotease DegS.
  
 
 0.850
sspB
Stringent starvation protein B.
    
 
 0.791
degQ
Periplasmic pH-dependent serine endoprotease DegQ precursor; Belongs to the peptidase S1C family.
  
 
 0.784
lptC
Lipopolysaccharide export system protein LptC; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family.
  
     0.754
yciS
Inner membrane protein YciS; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family.
  
     0.731
Your Current Organism:
Providencia rettgeri
NCBI taxonomy Id: 587
Other names: ATCC 29944, Bacterium rettgeri, CCUG 14804, CIP 103182, DSM 4542, LMG 3259, LMG:3259, NCTC 11801, P. rettgeri, Proteus rettgeri, Shigella rettgeri
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