| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APC12678.1 | APC12679.1 | RB151_030200 | RB151_030210 | Hypothetical protein; Belongs to the UPF0231 family. | Virulence protein. | 0.499 |
| APC12679.1 | APC12678.1 | RB151_030210 | RB151_030200 | Virulence protein. | Hypothetical protein; Belongs to the UPF0231 family. | 0.499 |
| APC12679.1 | birA | RB151_030210 | RB151_042920 | Virulence protein. | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.536 |
| APC12679.1 | citE | RB151_030210 | RB151_015720 | Virulence protein. | Citrate lyase subunit beta; Belongs to the HpcH/HpaI aldolase family. | 0.765 |
| APC12679.1 | nuoC | RB151_030210 | RB151_026700 | Virulence protein. | NADH-quinone oxidoreductase subunit C/D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the C-terminal section; belongs to the complex I 49 kDa subunit family. | 0.584 |
| APC12679.1 | sdhC | RB151_030210 | RB151_011180 | Virulence protein. | Succinate dehydrogenase cytochrome b556 subunit. | 0.439 |
| APC12679.1 | sipB | RB151_030210 | RB151_002100 | Virulence protein. | Cell invasion protein SipB. | 0.446 |
| APC12679.1 | ydjA | RB151_030210 | RB151_023780 | Virulence protein. | Putative NAD(P)H nitroreductase YdjA. | 0.466 |
| birA | APC12679.1 | RB151_042920 | RB151_030210 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Virulence protein. | 0.536 |
| birA | nuoC | RB151_042920 | RB151_026700 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | NADH-quinone oxidoreductase subunit C/D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the C-terminal section; belongs to the complex I 49 kDa subunit family. | 0.450 |
| birA | ydjA | RB151_042920 | RB151_023780 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Putative NAD(P)H nitroreductase YdjA. | 0.672 |
| citE | APC12679.1 | RB151_015720 | RB151_030210 | Citrate lyase subunit beta; Belongs to the HpcH/HpaI aldolase family. | Virulence protein. | 0.765 |
| nuoC | APC12679.1 | RB151_026700 | RB151_030210 | NADH-quinone oxidoreductase subunit C/D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the C-terminal section; belongs to the complex I 49 kDa subunit family. | Virulence protein. | 0.584 |
| nuoC | birA | RB151_026700 | RB151_042920 | NADH-quinone oxidoreductase subunit C/D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the C-terminal section; belongs to the complex I 49 kDa subunit family. | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.450 |
| nuoC | sdhC | RB151_026700 | RB151_011180 | NADH-quinone oxidoreductase subunit C/D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the C-terminal section; belongs to the complex I 49 kDa subunit family. | Succinate dehydrogenase cytochrome b556 subunit. | 0.988 |
| sdhC | APC12679.1 | RB151_011180 | RB151_030210 | Succinate dehydrogenase cytochrome b556 subunit. | Virulence protein. | 0.439 |
| sdhC | nuoC | RB151_011180 | RB151_026700 | Succinate dehydrogenase cytochrome b556 subunit. | NADH-quinone oxidoreductase subunit C/D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the C-terminal section; belongs to the complex I 49 kDa subunit family. | 0.988 |
| sipB | APC12679.1 | RB151_002100 | RB151_030210 | Cell invasion protein SipB. | Virulence protein. | 0.446 |
| ydjA | APC12679.1 | RB151_023780 | RB151_030210 | Putative NAD(P)H nitroreductase YdjA. | Virulence protein. | 0.466 |
| ydjA | birA | RB151_023780 | RB151_042920 | Putative NAD(P)H nitroreductase YdjA. | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.672 |