| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| btuR | cysG_1 | RB151_023340 | RB151_034960 | Cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | Siroheme synthase. | 0.840 |
| btuR | cysG_2 | RB151_023340 | RB151_034970 | Cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.571 |
| cysC | cysD | RB151_034930 | RB151_034950 | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. | Sulfate adenylyltransferase subunit 2. | 0.999 |
| cysC | cysG_1 | RB151_034930 | RB151_034960 | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. | Siroheme synthase. | 0.963 |
| cysC | cysG_2 | RB151_034930 | RB151_034970 | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.958 |
| cysC | cysH | RB151_034930 | RB151_034980 | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | 0.999 |
| cysC | cysI | RB151_034930 | RB151_034990 | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. | Sulfite reductase [NADPH] hemoprotein beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.989 |
| cysD | cysC | RB151_034950 | RB151_034930 | Sulfate adenylyltransferase subunit 2. | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. | 0.999 |
| cysD | cysG_1 | RB151_034950 | RB151_034960 | Sulfate adenylyltransferase subunit 2. | Siroheme synthase. | 0.943 |
| cysD | cysG_2 | RB151_034950 | RB151_034970 | Sulfate adenylyltransferase subunit 2. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.951 |
| cysD | cysH | RB151_034950 | RB151_034980 | Sulfate adenylyltransferase subunit 2. | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | 0.994 |
| cysD | cysI | RB151_034950 | RB151_034990 | Sulfate adenylyltransferase subunit 2. | Sulfite reductase [NADPH] hemoprotein beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.981 |
| cysG_1 | btuR | RB151_034960 | RB151_023340 | Siroheme synthase. | Cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | 0.840 |
| cysG_1 | cysC | RB151_034960 | RB151_034930 | Siroheme synthase. | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. | 0.963 |
| cysG_1 | cysD | RB151_034960 | RB151_034950 | Siroheme synthase. | Sulfate adenylyltransferase subunit 2. | 0.943 |
| cysG_1 | cysG_2 | RB151_034960 | RB151_034970 | Siroheme synthase. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.999 |
| cysG_1 | cysH | RB151_034960 | RB151_034980 | Siroheme synthase. | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | 0.898 |
| cysG_1 | cysI | RB151_034960 | RB151_034990 | Siroheme synthase. | Sulfite reductase [NADPH] hemoprotein beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.962 |
| cysG_1 | hemA | RB151_034960 | RB151_020490 | Siroheme synthase. | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.900 |
| cysG_1 | hemB | RB151_034960 | RB151_023230 | Siroheme synthase. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.911 |
