Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
tolCOuter membrane protein TolC precursor. (464 aa)    
Predicted Functional Partners:
acrA
Multidrug efflux pump subunit AcrA precursor; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
 0.978
acrB_2
Multidrug efflux pump subunit AcrB.
  
 0.961
arpC
Antibiotic efflux pump outer membrane protein ArpC precursor.
     
 0.919
ttgF
Toluene efflux pump outer membrane protein TtgF precursor.
     
0.908
hlyD
Hemolysin secretion protein D, chromosomal.
  
 
 0.873
mdtA_1
Multidrug resistance protein MdtA precursor; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 0.855
mdtA_2
Multidrug resistance protein MdtA precursor; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
 0.828
macB_1
Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
 
 0.814
cpxA
Sensor protein CpxA.
  
   
 0.796
bamA_2
Outer membrane protein assembly factor BamA precursor; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery.
 
   
 0.765
Your Current Organism:
Providencia rettgeri
NCBI taxonomy Id: 587
Other names: ATCC 29944, Bacterium rettgeri, CCUG 14804, CIP 103182, DSM 4542, LMG 3259, LMG:3259, NCTC 11801, P. rettgeri, Proteus rettgeri, Shigella rettgeri
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