STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
hypDHydrogenase isoenzymes formation protein HypD; Belongs to the HypD family. (370 aa)    
Predicted Functional Partners:
hypE
Hydrogenase isoenzymes formation protein HypE.
 
 
 0.998
hypC
Hydrogenase isoenzymes formation protein HypC.
 
 
 0.997
hypB
Hydrogenase isoenzymes nickel incorporation protein HypB.
 
  
 0.982
hypA
Hydrogenase nickel incorporation protein HybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
  
 0.948
hybC
Hydrogenase-2 large chain precursor; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.934
hybD
Hydrogenase 2 maturation protease.
 
   
 0.923
hypF
Carbamoyltransferase HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
  
 0.913
hybO
Hydrogenase-2 small chain precursor.
 
  
 0.908
ureG_1
Urease accessory protein UreG.
  
  
 0.692
ureG_2
Urease accessory protein UreG; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
  
  
 0.692
Your Current Organism:
Providencia rettgeri
NCBI taxonomy Id: 587
Other names: ATCC 29944, Bacterium rettgeri, CCUG 14804, CIP 103182, DSM 4542, LMG 3259, LMG:3259, NCTC 11801, P. rettgeri, Proteus rettgeri, Shigella rettgeri
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