guaD_2 protein (Providencia rettgeri) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

guaD_2

Guanine deaminase. (163 aa)

Predicted Functional Partners:

hisE

0.836

birA

0.800

guaA

0.502

truA

0.442

ydjA

0.421

tsaB

0.411

fosA

0.404

Your Current Organism:

Providencia rettgeri

NCBI taxonomy Id: 587
Other names: ATCC 29944, Bacterium rettgeri, CCUG 14804, CIP 103182, DSM 4542, LMG 3259, LMG:3259, NCTC 11801, P. rettgeri, Proteus rettgeri, Shigella rettgeri

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
birA	fosA	RB151_042920	RB151_019080	Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.	Glutathione transferase FosA.	0.474
birA	guaA	RB151_042920	RB151_024330	Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	0.700
birA	guaD_2	RB151_042920	RB151_038020	Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.	Guanine deaminase.	0.800
birA	tsaB	RB151_042920	RB151_021080	Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.	tRNA threonylcarbamoyladenosine biosynthesis protein TsaB.	0.921
birA	ydjA	RB151_042920	RB151_023780	Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.	Putative NAD(P)H nitroreductase YdjA.	0.672
fosA	birA	RB151_019080	RB151_042920	Glutathione transferase FosA.	Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.	0.474
fosA	guaD_2	RB151_019080	RB151_038020	Glutathione transferase FosA.	Guanine deaminase.	0.404
fosA	ydjA	RB151_019080	RB151_023780	Glutathione transferase FosA.	Putative NAD(P)H nitroreductase YdjA.	0.466
guaA	birA	RB151_024330	RB151_042920	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.	0.700
guaA	guaD_2	RB151_024330	RB151_038020	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	Guanine deaminase.	0.502
guaA	hisE	RB151_024330	RB151_012420	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	Phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family.	0.530
guaA	tsaB	RB151_024330	RB151_021080	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	tRNA threonylcarbamoyladenosine biosynthesis protein TsaB.	0.558
guaD_2	birA	RB151_038020	RB151_042920	Guanine deaminase.	Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.	0.800
guaD_2	fosA	RB151_038020	RB151_019080	Guanine deaminase.	Glutathione transferase FosA.	0.404
guaD_2	guaA	RB151_038020	RB151_024330	Guanine deaminase.	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	0.502
guaD_2	hisE	RB151_038020	RB151_012420	Guanine deaminase.	Phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family.	0.836
guaD_2	truA	RB151_038020	RB151_026970	Guanine deaminase.	tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.	0.442
guaD_2	tsaB	RB151_038020	RB151_021080	Guanine deaminase.	tRNA threonylcarbamoyladenosine biosynthesis protein TsaB.	0.411
guaD_2	ydjA	RB151_038020	RB151_023780	Guanine deaminase.	Putative NAD(P)H nitroreductase YdjA.	0.421
hisE	guaA	RB151_012420	RB151_024330	Phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family.	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	0.530

page 1 of 2

Server load: low (12%) [HD]

Permalink

Network

Neighborhood

Textmining

Co-occurrence

Experiments

Co-expression

Databases

Fusion

© STRING Consortium 2026

Credits

Access

Info

About