| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APC11004.1 | birA | RB151_013190 | RB151_042920 | ComEC family competence protein. | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.673 |
| APC11004.1 | murB_1 | RB151_013190 | RB151_042930 | ComEC family competence protein. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.420 |
| APC11004.1 | murB_2 | RB151_013190 | RB151_042940 | ComEC family competence protein. | UDP-N-acetylenolpyruvoylglucosamine reductase. | 0.420 |
| birA | APC11004.1 | RB151_042920 | RB151_013190 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | ComEC family competence protein. | 0.673 |
| birA | guaA | RB151_042920 | RB151_024330 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.700 |
| birA | murB_1 | RB151_042920 | RB151_042930 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.920 |
| birA | murB_2 | RB151_042920 | RB151_042940 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | UDP-N-acetylenolpyruvoylglucosamine reductase. | 0.825 |
| ddl | ddlA | RB151_030430 | RB151_022050 | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | D-alanine--D-alanine ligase A; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | 0.903 |
| ddl | ftsQ | RB151_030430 | RB151_030420 | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | 0.988 |
| ddl | murB_1 | RB151_030430 | RB151_042930 | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.552 |
| ddl | murB_2 | RB151_030430 | RB151_042940 | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | UDP-N-acetylenolpyruvoylglucosamine reductase. | 0.441 |
| ddl | murG | RB151_030430 | RB151_030450 | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.965 |
| ddlA | ddl | RB151_022050 | RB151_030430 | D-alanine--D-alanine ligase A; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | 0.903 |
| ddlA | ftsQ | RB151_022050 | RB151_030420 | D-alanine--D-alanine ligase A; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | 0.933 |
| ddlA | murB_1 | RB151_022050 | RB151_042930 | D-alanine--D-alanine ligase A; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.555 |
| ddlA | murB_2 | RB151_022050 | RB151_042940 | D-alanine--D-alanine ligase A; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | UDP-N-acetylenolpyruvoylglucosamine reductase. | 0.441 |
| ddlA | murG | RB151_022050 | RB151_030450 | D-alanine--D-alanine ligase A; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.893 |
| ftsQ | ddl | RB151_030420 | RB151_030430 | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | 0.988 |
| ftsQ | ddlA | RB151_030420 | RB151_022050 | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | D-alanine--D-alanine ligase A; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | 0.933 |
| ftsQ | murB_1 | RB151_030420 | RB151_042930 | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.527 |