node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFO89312.1 | SFP25182.1 | SAMN05421810_101316 | SAMN05421810_10230 | FMN-dependent dehydrogenase, includes L-lactate dehydrogenase and type II isopentenyl diphosphate isomerase. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.837 |
SFO89312.1 | SFP25419.1 | SAMN05421810_101316 | SAMN05421810_10237 | FMN-dependent dehydrogenase, includes L-lactate dehydrogenase and type II isopentenyl diphosphate isomerase. | Acetolactate synthase, small subunit. | 0.848 |
SFO89312.1 | SFQ07753.1 | SAMN05421810_101316 | SAMN05421810_104404 | FMN-dependent dehydrogenase, includes L-lactate dehydrogenase and type II isopentenyl diphosphate isomerase. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.892 |
SFO89312.1 | SFQ53764.1 | SAMN05421810_101316 | SAMN05421810_1098 | FMN-dependent dehydrogenase, includes L-lactate dehydrogenase and type II isopentenyl diphosphate isomerase. | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | 0.896 |
SFO89312.1 | SFQ64239.1 | SAMN05421810_101316 | SAMN05421810_111115 | FMN-dependent dehydrogenase, includes L-lactate dehydrogenase and type II isopentenyl diphosphate isomerase. | 2-oxoglutarate ferredoxin oxidoreductase subunit alpha. | 0.904 |
SFO89312.1 | leuA | SAMN05421810_101316 | SAMN05421810_10342 | FMN-dependent dehydrogenase, includes L-lactate dehydrogenase and type II isopentenyl diphosphate isomerase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.852 |
SFP25182.1 | SFO89312.1 | SAMN05421810_10230 | SAMN05421810_101316 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | FMN-dependent dehydrogenase, includes L-lactate dehydrogenase and type II isopentenyl diphosphate isomerase. | 0.837 |
SFP25182.1 | SFP25419.1 | SAMN05421810_10230 | SAMN05421810_10237 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Acetolactate synthase, small subunit. | 0.947 |
SFP25182.1 | SFQ07753.1 | SAMN05421810_10230 | SAMN05421810_104404 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.847 |
SFP25182.1 | SFQ53764.1 | SAMN05421810_10230 | SAMN05421810_1098 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | 0.864 |
SFP25182.1 | SFQ64239.1 | SAMN05421810_10230 | SAMN05421810_111115 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-oxoglutarate ferredoxin oxidoreductase subunit alpha. | 0.891 |
SFP25182.1 | ilvC | SAMN05421810_10230 | SAMN05421810_10236 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.863 |
SFP25182.1 | leuA | SAMN05421810_10230 | SAMN05421810_10342 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.838 |
SFP25182.1 | leuC | SAMN05421810_10230 | SAMN05421810_10222 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.982 |
SFP25182.1 | leuD | SAMN05421810_10230 | SAMN05421810_10221 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.974 |
SFP25419.1 | SFO89312.1 | SAMN05421810_10237 | SAMN05421810_101316 | Acetolactate synthase, small subunit. | FMN-dependent dehydrogenase, includes L-lactate dehydrogenase and type II isopentenyl diphosphate isomerase. | 0.848 |
SFP25419.1 | SFP25182.1 | SAMN05421810_10237 | SAMN05421810_10230 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.947 |
SFP25419.1 | SFQ53764.1 | SAMN05421810_10237 | SAMN05421810_1098 | Acetolactate synthase, small subunit. | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | 0.989 |
SFP25419.1 | SFQ64239.1 | SAMN05421810_10237 | SAMN05421810_111115 | Acetolactate synthase, small subunit. | 2-oxoglutarate ferredoxin oxidoreductase subunit alpha. | 0.902 |
SFP25419.1 | ilvC | SAMN05421810_10237 | SAMN05421810_10236 | Acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |