node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cpap_0933 | Cpap_3360 | Cpap_0933 | Cpap_3360 | PFAM: pyruvate carboxyltransferase; KEGG: cce:Ccel_2177 pyruvate carboxyltransferase. | KEGG: cce:Ccel_1264 dihydroxy-acid and 6-phosphogluconate dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.673 |
Cpap_0933 | ilvC | Cpap_0933 | Cpap_1391 | PFAM: pyruvate carboxyltransferase; KEGG: cce:Ccel_2177 pyruvate carboxyltransferase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.659 |
Cpap_0933 | ilvD | Cpap_0933 | Cpap_1974 | PFAM: pyruvate carboxyltransferase; KEGG: cce:Ccel_2177 pyruvate carboxyltransferase. | TIGRFAM: dihydroxy-acid dehydratase; KEGG: cce:Ccel_0302 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.673 |
Cpap_0933 | leuB | Cpap_0933 | Cpap_2199 | PFAM: pyruvate carboxyltransferase; KEGG: cce:Ccel_2177 pyruvate carboxyltransferase. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.748 |
Cpap_0933 | leuC | Cpap_0933 | Cpap_2197 | PFAM: pyruvate carboxyltransferase; KEGG: cce:Ccel_2177 pyruvate carboxyltransferase. | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.899 |
Cpap_0933 | leuD | Cpap_0933 | Cpap_2198 | PFAM: pyruvate carboxyltransferase; KEGG: cce:Ccel_2177 pyruvate carboxyltransferase. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.903 |
Cpap_1389 | Cpap_3360 | Cpap_1389 | Cpap_3360 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; KEGG: cce:Ccel_3433 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | KEGG: cce:Ccel_1264 dihydroxy-acid and 6-phosphogluconate dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.880 |
Cpap_1389 | ilvC | Cpap_1389 | Cpap_1391 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; KEGG: cce:Ccel_3433 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.768 |
Cpap_1389 | ilvD | Cpap_1389 | Cpap_1974 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; KEGG: cce:Ccel_3433 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | TIGRFAM: dihydroxy-acid dehydratase; KEGG: cce:Ccel_0302 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.921 |
Cpap_1389 | leuA | Cpap_1389 | Cpap_0604 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; KEGG: cce:Ccel_3433 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.771 |
Cpap_1389 | leuA-2 | Cpap_1389 | Cpap_1390 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; KEGG: cce:Ccel_3433 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.884 |
Cpap_1389 | leuB | Cpap_1389 | Cpap_2199 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; KEGG: cce:Ccel_3433 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.787 |
Cpap_1389 | leuC | Cpap_1389 | Cpap_2197 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; KEGG: cce:Ccel_3433 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.935 |
Cpap_1389 | leuD | Cpap_1389 | Cpap_2198 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; KEGG: cce:Ccel_3433 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.936 |
Cpap_2204 | Cpap_3360 | Cpap_2204 | Cpap_3360 | PFAM: pyruvate carboxyltransferase; KEGG: cce:Ccel_2177 pyruvate carboxyltransferase. | KEGG: cce:Ccel_1264 dihydroxy-acid and 6-phosphogluconate dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.673 |
Cpap_2204 | ilvC | Cpap_2204 | Cpap_1391 | PFAM: pyruvate carboxyltransferase; KEGG: cce:Ccel_2177 pyruvate carboxyltransferase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.659 |
Cpap_2204 | ilvD | Cpap_2204 | Cpap_1974 | PFAM: pyruvate carboxyltransferase; KEGG: cce:Ccel_2177 pyruvate carboxyltransferase. | TIGRFAM: dihydroxy-acid dehydratase; KEGG: cce:Ccel_0302 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.673 |
Cpap_2204 | leuB | Cpap_2204 | Cpap_2199 | PFAM: pyruvate carboxyltransferase; KEGG: cce:Ccel_2177 pyruvate carboxyltransferase. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.748 |
Cpap_2204 | leuC | Cpap_2204 | Cpap_2197 | PFAM: pyruvate carboxyltransferase; KEGG: cce:Ccel_2177 pyruvate carboxyltransferase. | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.897 |
Cpap_2204 | leuD | Cpap_2204 | Cpap_2198 | PFAM: pyruvate carboxyltransferase; KEGG: cce:Ccel_2177 pyruvate carboxyltransferase. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.902 |