STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cpap_2206PFAM: isochorismatase hydrolase; KEGG: geo:Geob_0184 isochorismatase hydrolase. (181 aa)    
Predicted Functional Partners:
Cpap_4106
TIGRFAM: amino acid adenylation domain protein; PFAM: AMP-dependent synthetase and ligase; condensation domain protein; KR domain protein; Beta-ketoacyl synthase; phosphopantetheine-binding; KEGG: cce:Ccel_2331 amino acid adenylation domain protein; SMART: Polyketide synthase/Fatty acid synthase, KR.
  
 0.675
Cpap_0010
Manually curated; KEGG: cpi:Cpin_5290 erythronolide synthase, 6-methylsalicylic acid synthase; PFAM: Beta-ketoacyl synthase; KR domain protein; phosphopantetheine-binding.
  
 0.595
Cpap_1105
PFAM: ThiJ/PfpI domain-containing protein; KEGG: amt:Amet_1453 ThiJ/PfpI domain-containing protein.
 
    0.565
Cpap_4108
KEGG: cce:Ccel_2329 amino acid adenylation domain protein; TIGRFAM: amino acid adenylation domain protein; FkbH like protein; HAD-superfamily phosphatase, subfamily IIIC; PFAM: AMP-dependent synthetase and ligase; condensation domain protein; NLI interacting domain protein; phosphopantetheine-binding; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 0.551
nnrE
Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...]
   
    0.530
cobB
Silent information regulator protein Sir2; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily.
  
 0.526
Cpap_1755
Salicylate synthase; KEGG: dae:Dtox_2676 AMP-dependent synthetase and ligase; TIGRFAM: salicylate synthase; PFAM: Chorismate binding-like.
    
 0.517
Cpap_1771
PFAM: AMP-dependent synthetase and ligase; KEGG: dae:Dtox_2676 AMP-dependent synthetase and ligase.
    
 0.517
Cpap_2207
KEGG: cbk:CLL_A3535 transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; SMART: Helix-turn-helix, AraC domain.
       0.511
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
 
 0.510
Your Current Organism:
Ruminiclostridium papyrosolvens DSM 2782
NCBI taxonomy Id: 588581
Other names: Clostridium papyrosolvens DSM 2782, R. papyrosolvens DSM 2782
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