node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cpap_1094 | Cpap_3912 | Cpap_1094 | Cpap_3912 | TIGRFAM: phosphoribosylformylglycinamidine synthase; KEGG: cce:Ccel_0499 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. | KEGG: cce:Ccel_1144 FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SirA-like domain-containing protein; DsrE family protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; Rhodanese domain protein; SMART: Rhodanese domain protein; Belongs to the sulfur carrier protein TusA family. | 0.492 |
Cpap_1094 | fhs | Cpap_1094 | Cpap_2099 | TIGRFAM: phosphoribosylformylglycinamidine synthase; KEGG: cce:Ccel_0499 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. | Formate--tetrahydrofolate ligase; Manually curated; KEGG: cce:Ccel_0018 formate-tetrahydrofolate ligase FTHFS; PFAM: formate-tetrahydrofolate ligase FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | 0.982 |
Cpap_1094 | folD | Cpap_1094 | Cpap_1583 | TIGRFAM: phosphoribosylformylglycinamidine synthase; KEGG: cce:Ccel_0499 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.905 |
Cpap_1094 | glyA | Cpap_1094 | Cpap_3226 | TIGRFAM: phosphoribosylformylglycinamidine synthase; KEGG: cce:Ccel_0499 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.994 |
Cpap_1094 | purA | Cpap_1094 | Cpap_0817 | TIGRFAM: phosphoribosylformylglycinamidine synthase; KEGG: cce:Ccel_0499 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.990 |
Cpap_1094 | purD | Cpap_1094 | Cpap_0931 | TIGRFAM: phosphoribosylformylglycinamidine synthase; KEGG: cce:Ccel_0499 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. | TIGRFAM: phosphoribosylamine/glycine ligase; KEGG: cce:Ccel_2180 phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. | 0.999 |
Cpap_1094 | purH | Cpap_1094 | Cpap_0930 | TIGRFAM: phosphoribosylformylglycinamidine synthase; KEGG: cce:Ccel_0499 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. | SMART: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: cce:Ccel_2181 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein. | 0.999 |
Cpap_1094 | purN | Cpap_1094 | Cpap_0929 | TIGRFAM: phosphoribosylformylglycinamidine synthase; KEGG: cce:Ccel_0499 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.999 |
Cpap_1094 | tpiA | Cpap_1094 | Cpap_4188 | TIGRFAM: phosphoribosylformylglycinamidine synthase; KEGG: cce:Ccel_0499 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.770 |
Cpap_1914 | glyA | Cpap_1914 | Cpap_3226 | TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; KEGG: cce:Ccel_0259 sugar-phosphate isomerase, RpiB/LacA/LacB family; PFAM: Ribose/galactose isomerase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.935 |
Cpap_1914 | tpiA | Cpap_1914 | Cpap_4188 | TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; KEGG: cce:Ccel_0259 sugar-phosphate isomerase, RpiB/LacA/LacB family; PFAM: Ribose/galactose isomerase. | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.715 |
Cpap_3912 | Cpap_1094 | Cpap_3912 | Cpap_1094 | KEGG: cce:Ccel_1144 FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SirA-like domain-containing protein; DsrE family protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; Rhodanese domain protein; SMART: Rhodanese domain protein; Belongs to the sulfur carrier protein TusA family. | TIGRFAM: phosphoribosylformylglycinamidine synthase; KEGG: cce:Ccel_0499 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. | 0.492 |
Cpap_3912 | fhs | Cpap_3912 | Cpap_2099 | KEGG: cce:Ccel_1144 FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SirA-like domain-containing protein; DsrE family protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; Rhodanese domain protein; SMART: Rhodanese domain protein; Belongs to the sulfur carrier protein TusA family. | Formate--tetrahydrofolate ligase; Manually curated; KEGG: cce:Ccel_0018 formate-tetrahydrofolate ligase FTHFS; PFAM: formate-tetrahydrofolate ligase FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | 0.475 |
Cpap_3912 | folD | Cpap_3912 | Cpap_1583 | KEGG: cce:Ccel_1144 FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SirA-like domain-containing protein; DsrE family protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; Rhodanese domain protein; SMART: Rhodanese domain protein; Belongs to the sulfur carrier protein TusA family. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.713 |
Cpap_3912 | glyA | Cpap_3912 | Cpap_3226 | KEGG: cce:Ccel_1144 FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SirA-like domain-containing protein; DsrE family protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; Rhodanese domain protein; SMART: Rhodanese domain protein; Belongs to the sulfur carrier protein TusA family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.931 |
Cpap_3912 | tpiA | Cpap_3912 | Cpap_4188 | KEGG: cce:Ccel_1144 FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SirA-like domain-containing protein; DsrE family protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; Rhodanese domain protein; SMART: Rhodanese domain protein; Belongs to the sulfur carrier protein TusA family. | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.806 |
fhs | Cpap_1094 | Cpap_2099 | Cpap_1094 | Formate--tetrahydrofolate ligase; Manually curated; KEGG: cce:Ccel_0018 formate-tetrahydrofolate ligase FTHFS; PFAM: formate-tetrahydrofolate ligase FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | TIGRFAM: phosphoribosylformylglycinamidine synthase; KEGG: cce:Ccel_0499 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. | 0.982 |
fhs | Cpap_3912 | Cpap_2099 | Cpap_3912 | Formate--tetrahydrofolate ligase; Manually curated; KEGG: cce:Ccel_0018 formate-tetrahydrofolate ligase FTHFS; PFAM: formate-tetrahydrofolate ligase FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | KEGG: cce:Ccel_1144 FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SirA-like domain-containing protein; DsrE family protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; Rhodanese domain protein; SMART: Rhodanese domain protein; Belongs to the sulfur carrier protein TusA family. | 0.475 |
fhs | folD | Cpap_2099 | Cpap_1583 | Formate--tetrahydrofolate ligase; Manually curated; KEGG: cce:Ccel_0018 formate-tetrahydrofolate ligase FTHFS; PFAM: formate-tetrahydrofolate ligase FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.997 |
fhs | glyA | Cpap_2099 | Cpap_3226 | Formate--tetrahydrofolate ligase; Manually curated; KEGG: cce:Ccel_0018 formate-tetrahydrofolate ligase FTHFS; PFAM: formate-tetrahydrofolate ligase FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.968 |