STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cpap_3647TIGRFAM: threonine synthase; KEGG: cce:Ccel_1450 threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. (507 aa)    
Predicted Functional Partners:
Cpap_3649
PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: cce:Ccel_1452 homoserine dehydrogenase.
 
 0.992
serC
Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.
   
 0.907
leuD
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
  
  
 0.883
Cpap_1622
PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: cce:Ccel_0635 aromatic amino acid beta-eliminating lyase/threonine aldolase.
   
 0.871
Cpap_3648
PFAM: amino acid-binding ACT domain protein; KEGG: cce:Ccel_1451 hypothetical protein; Belongs to the UPF0735 family.
    
 0.837
Cpap_0398
PFAM: amino acid-binding ACT domain protein; KEGG: cce:Ccel_0524 amino acid-binding ACT domain protein.
  
 
 0.789
Cpap_0402
KEGG: cce:Ccel_0528 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family.
  
 
 0.789
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
  
 0.751
Cpap_3773
PFAM: Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein; KEGG: cce:Ccel_3224 alcohol dehydrogenase GroES domain protein.
     
 0.750
Cpap_3687
TIGRFAM: 4-hydroxythreonine-4-phosphate dehydrogenase; KEGG: cce:Ccel_2603 4-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate biosynthetic protein PdxA; Belongs to the PdxA family.
    
  0.738
Your Current Organism:
Ruminiclostridium papyrosolvens DSM 2782
NCBI taxonomy Id: 588581
Other names: Clostridium papyrosolvens DSM 2782, R. papyrosolvens DSM 2782
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