STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0BK44_PARTEDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1196 aa)    
Predicted Functional Partners:
A0CF77_PARTE
TOPEUc domain-containing protein.
   
 
 0.940
A0DKX8_PARTE
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
   
 
 0.940
A0D0A5_PARTE
Structural maintenance of chromosomes protein.
   
 
 0.875
A0DC09_PARTE
Uncharacterized protein.
   
 
 0.875
A0D2P6_PARTE
Ubiquitin-like domain-containing protein.
    
 0.814
A0EG33_PARTE
Ubiquitin-like domain-containing protein.
    
 0.814
SUMOIII
Small ubiquitin-related modifier III.
    
 0.814
SUMOII
Small ubiquitin-related modifier II.
    
 0.814
SUMOI
Small ubiquitin-related modifier I.
    
 0.814
A0CU10_PARTE
Uncharacterized protein.
   
 
 0.798
Your Current Organism:
Paramecium tetraurelia
NCBI taxonomy Id: 5888
Other names: P. tetraurelia, Paramecium aurelia syngen 4
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.