STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0DEK9_PARTEDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (859 aa)    
Predicted Functional Partners:
A0DVC0_PARTE
ERCC4 domain-containing protein.
    
 0.993
A0BPX8_PARTE
ERCC4 domain-containing protein.
    
 0.983
A0BH34_PARTE
Helicase ATP-binding domain-containing protein.
  
 0.961
A0BH35_PARTE
ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.
  
 0.961
A0BKF1_PARTE
Uncharacterized protein.
  
 0.961
A0C7G1_PARTE
ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.
  
 0.961
A0DX38_PARTE
Uncharacterized protein.
  
 0.961
A0E2K1_PARTE
Uncharacterized protein.
  
 0.961
A0E9E2_PARTE
Uncharacterized protein.
   
 
 0.958
A0CV46_PARTE
AAA_23 domain-containing protein.
  
 0.926
Your Current Organism:
Paramecium tetraurelia
NCBI taxonomy Id: 5888
Other names: P. tetraurelia, Paramecium aurelia syngen 4
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